Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum:A Literature Review  

作　　者：Putri Mirani Peby Maulina Lestari Krisna Murti Iche Andriyani Liberty Hana Andrina Cindy Kesty Bella Stevanny 

机构地区：[1]Division of Maternal-Fetal Medicine,Department of Obstetrics and Gynecology,Dr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya University,Palembang,South Sumatera,Indonesia [2]Division of Hematolymphoid and Endocrinology,Department of Pathological Anatomy,Dr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya University,Palembang,Indonesia [3]Department of Public Health and Community Medicine,Faculty of Medicine,Sriwijaya University,Palembang,Indonesia [4]Department of Obstetrics and Gynecology,Dr.Mohammad Hoesin General Hospital/Faculty of Medicine Sriwijaya University,Palembang,South Sumatera,Indonesia.

出　　处：《Maternal-Fetal Medicine》2024年第2期97-101,共5页母胎医学杂志（英文）

摘　　要：The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections.A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of trophoblasts.Matrix metalloproteinase(MMP)is crucial in every step of wound healing as it alters the wound matrix,facilitating cell migration,as well as tissue remodeling.MMP-9 expression is higher in placental and decidual tissue in cases of placenta accreta.Based on these findings,assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker.

关 键 词：BIOMARKER ETIOPATHOGENESIS Matrix metalloproteinase MMP-9 Placenta accreta spectrum disorder 

分 类 号：R714.56[医药卫生—妇产科学]