肾移植患者载脂蛋白E基因型与血脂水平相关性研究  

Relationship between ApoE Genotype and Blood Lipid Levels in Renal Transplant Patients

作　　者：张晓斐 苏明 王思旭 赵美姗 仇炜[1] ZHANG Xiaofei;SU Ming;WANG Sixu;ZHAO Meishan;QIU Wei(Department of Urology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Clinical Laboratory,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]首都医科大学附属北京友谊医院泌尿外科,北京100050 [2]北京大学人民医院检验科,北京100044

出　　处：《中国分子心脏病学杂志》2024年第2期6001-6004,共4页Molecular Cardiology of China

基　　金：北京市医院管理中心青年人才培养“青苗”计划(QML20210105)。

摘　　要：目的分析同种异体肾移植受者载脂蛋白E(ApoE)基因型的分布特点及其与血脂水平的相关性。方法本研究纳入在北京友谊医院接受肾移植手术且进行ApoE基因型检测的80例患者,分析总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)以及高密度脂蛋白胆固醇(HDL-C)的变化。将纳入研究的肾移植患者按ApoE基因型分为E2组(包括E2/E2和E2/E3型)、E3组(包括E3/E3和E2/E4型)和E4组(包括E3/E4和E4/E4型),分析ApoE基因型的分布情况,并探讨ApoE基因多态性与血脂水平的关系。结果在80例患者中ApoE基因E2/E3型11例,E3/E3型59例,E2/E4型1例,E3/E4型8例,E4/E4型1例。等位基因频率为:e2,7.50%;e3,85.63%;e4,6.87%。三组患者LDL-C及TC无统计学差异(P均>0.05),E4组的TG水平显著高于E3组,差异有统计学意义(P<0.05)。E4组和E2组的HDL-C水平显著低于E3组,差异有统计学意义(P均<0.05)。结论肾移植患者TG和HDL-C水平与ApoE基因多态性有关,TC和LDL-C水平与ApoE基因多态性无关。在肾移植患者中进行ApoE基因型检测有助于个体化降血脂治疗。Objective To analyze the relationship between ApoE gene polymorphism and blood lipid levels in renal transplant patients.Methods Eighty patients undergoing renal transplantation in Beijing Friendship Hospital with ApoE genotype detection were enrolled in this study,the serum cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL⁃C)and high density lipoprotein cholesterol(HDL⁃C)were analyzed.The patients included in the study were divided into E2(including E2/E2 and E2/E3 genotypes),E3(including E3/E3 and E2/E4 genotypes)and E4(including E3/E4 and E4/E4 genotypes)groups according to ApoE genotype.The serum lipid levels of each group were compared to investigate the relationship between ApoE polymorphism and blood lipid.Results Among 80 patients,there were 11 cases of E2/E3 genotype,59 cases of E3/E3 genotype,1 case of E2/E4 genotype,8 cases of E3/E4 genotype and 1 case of E4/E4 genotype.The frequencies of alleles were:e27.50%,e385.63%and e46.87%.LDL⁃C levels in E2,E3 and E4 groups were comparable(all P>0.05).The serum TC and TG levels in patients of E4 group were significantly higher than those in E3 group(all P<0.05).The serum HDL⁃C levels in patients of E4 and E2 group were significantly lower than those in E3 group(all P<0.05).Conclusion The levels of TG and HDL⁃C in renal transplantation recipients are associated with ApoE polymorphism,while the levels of TC and LDL⁃C are not associated with ApoE polymorphism.Our data indicated that the detection of ApoE genotype in recipients of kidney transplantation may be benefit for the individualized controlling of hyperlipidemia.

关 键 词：肾移植 载脂蛋白E 血脂 基因多态性 

分 类 号：R74[医药卫生—神经病学与精神病学]