肠道菌群与微RNA互相作用在功能性肠病中的研究进展  

Research progress on the interaction between intestinal flora and miRNA in functional bowel disease

作　　者：汪军强 魏清琳 汪龙德 邢方玉 王博 祁冬梅 牛旭梅 WANG Junqiang;WEI Qinglin;WANG Longde;XING Fangyu;WANG Bo;QI Dongmei;NIU Xumei(Comprehensive Treatment Center of Traditional Chinese Medicine,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;Clinical Center of Acupuncture and Massage,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;Department of Spleen and Stomach Diseases,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;Changjia Xiang Outpatient Department,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;College of Acupuncture and Massage,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃中医药大学附属医院中医综合治疗中心,甘肃兰州730000 [2]甘肃中医药大学附属医院针灸推拿临床医学中心,甘肃兰州730000 [3]甘肃中医药大学附属医院脾胃病科,甘肃兰州730000 [4]甘肃中医药大学附属医院畅家巷门诊部,甘肃兰州730000 [5]甘肃中医药大学针灸推拿学院,甘肃兰州730000

出　　处：《安徽医药》2024年第7期1277-1280,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(82160883);甘肃省科技计划项目(18JR2FA002);敦煌医学与转化教育部重点实验室开放基金项目(DHYX-18-25)。

摘　　要：功能性肠病作为临床常见病,其发病机制尚不明确。研究表明,肠道微生物与微RNA(miRNA)之间存在错综复杂的双向交流和串扰,其中miRNA靶向调控肠道细菌生长与平衡,肠道菌群也能调节miRNA的表达。基于此,该研究对肠道菌群与miRNA及二者相互作用进行概述,重点阐述这种互作机制对功能性肠病的影响,并进一步探讨二者双向交流在功能性肠病中所产生的诊断能力和治疗潜力。As a common clinical disease,the pathogenesis of functional bowel disease is not clear.Studies have shown that there are complex two-way communication and crosstalk between microorganisms and miRNA,in which miRNA targets to regulate the growth and balance of intestinal bacteria,and intestinal flora can also regulate the expression of miRNA.Based on this,this paper summarizes the interaction between intestinal flora and miRNA,focuses on the influence of this interaction mechanism on functional bowel disease,and further discusses the diagnostic ability and therapeutic potential of two-way communication in functional bowel disease.

关 键 词：功能性肠病 肠道菌群 微RNA 相互作用 诊断能力 

分 类 号：R574[医药卫生—消化系统]