组织桥接整合因子1、Ⅰ型胶原蛋白基因、核转运蛋白基因2与三阴性乳腺癌术后复发关系  

Relationship between the expression of tissue bridging integration factor 1,type I collagen gene,nuclear transfer protein gene 2 and postoperative recurrence of triple negative breast cancer

作　　者：郇金亮[1] 高庆佳 唐小龙[1] 易宜 吴凯铠 黄雄[1] HUAN Jinliang;GAO Qingjia;TANG Xiaolong;YI Yi;WU Kaikai;HUANG Xiong(Department of General Surgery,The Eighth People´s Hospital of Shanghai,Shanghai 200235,China;Department of Neurosurgery,Qingzhou People´s Hospital,Qingzhou,Shandong 262599,China)

机构地区：[1]上海市第八人民医院普外科,上海200235 [2]青州市人民医院神经外科,山东青州262599

出　　处：《安徽医药》2024年第7期1343-1347,共5页Anhui Medical and Pharmaceutical Journal

基　　金：上海市卫生系统优秀青年医学人才培养项目(PWRq2018-911)。

摘　　要：目的探究组织桥接整合因子1(BIN1)、Ⅰ型胶原蛋白基因(COL1A1)、核转运蛋白基因2(KPNA2)表达与三阴性乳腺癌(TNBC)术后复发关系及联合检测意义。方法选取2019年5月至2020年5月上海市第八人民医院行手术治疗的TNBC病人80例,根据术后2年是否复发分为复发组、未复发组,比较两组临床资料、组织BIN1、COL1A1、KPNA2基因表达,复发的相关影响因素采用单因素与多因素logistic回归分析,组织BIN1、COL1A1、KPNA2基因表达预测术后复发的价值采用受试者操作特征曲线(ROC曲线)分析,组织BIN1、COL1A1、KPNA2基因表达与复发时间关系采用Pearson分析,比较不同组织BIN1、COL1A1、KPNA2基因表达病人无复发生存期(RFS)。结果复发组T分期、N分期与未复发组比较,差异有统计学意义(P<0.05);复发组组织BIN1mRNA表达为0.24±0.07,低于未复发组的0.35±0.10(P<0.05),复发组组织COL1A1mRNA、KPNA2mRNA表达分别为2.07±0.62、2.91±0.84,高于未复发组的1.48±0.43、1.85±0.60(P<0.05);T分期、N分期、COL1A1 mRNA、KPNA2 mRNA均是复发相关独立危险因素,BIN1 mRNA是复发相关独立保护因素(P<0.05);BIN1 mRNA、COL1A1 mRNA、KPNA2 mRNA的AUC分别为0.76、0.80、0.78,三者联合的AUC为0.94;BIN1mRNA与复发时间呈负相关(r=-0.79,P<0.001),COL1A1mRNA、KPNA2mRNA与复发时间呈正相关(r=0.77、0.78,均P<0.001);BIN1mRNA高水平病人RFS长于低水平病人,COL1A1mRNA、KPNA2mRNA高水平病人RFS短于低水平病人(P<0.05)。结论BIN1mRNA、COL1A1mRNA、KPNA2mRNA与TNBC术后复发风险、复发时间有关,联合检测可作为早期预测术后复发的一个可靠方案,为临床治疗提供重要的参考信息。Objective To explore the relationship between the expression of tissue bridging integration factor 1(BIN1),collagen type I gene(COL1A1),nuclear transport protein gene 2(KPNA2)and postoperative recurrence of triple negative breast cancer(TNBC)and the significance of combined detection.Methods Eighty patients with TNBC who underwent surgical treatment in the Eighth People´s Hospital from May 2019 to May 2020 were selected and categorized into recurrence group and non-recurrence group according to whether they recurred 2 years after surgery.The clinical data,tissue BIN1,COL1A1,and KPNA2 gene expressions were compared between the two groups,the related influencing factors of recurrence were analyzed by univariate and multivariate Logistic regression analysis,the value of tissue BIN1,COL1A1,KPNA2 gene expression in predicting postoperative recurrence was analyzed by receiver operating characteristic(ROC)curve.Pearson analysis was used to analyze the relationship between the tissue BIN1,COL1A1,KPNA2 gene expression and the recurrence time.The relapse-free survival(RFS)in patients with different tissue BIN1,COL1A1 and KPNA2 gene expression was compared.Results There were significant differences in T and N Staging between the recurrence group and the non-recurrence group(P<0.05);the expression of BIN1 mRNA in the recurrent group was 0.24±0.07,which was lower than that in the non-recurrent group 0.35±0.10(P<0.05);the expressions of COL1A1 mRNA and KPNA2 mRNA in the recurrent group were 2.07±0.62 and 2.91±0.84,respectively,which were higher than those in the non-recurrent group 1.48±0.43 and 1.85±0.60(P<0.05);T staging,N staging,COL1A1 mRNA and KPNA2 mRNA were independent risk factors for recurrence,and BIN1 mRNA was an independent protective factor for recurrence(P<0.05).The AUCs of BIN1 mRNA,COL1A1 mRNA,and KPNA2 mRNA were 0.76,0.80,and 0.78,respectively,and the combined AUC of the three was 0.94;BIN1 mRNA was negatively correlated with recurrence time(r=−0.79,P<0.001).There was a positive correlation with the r

关 键 词：三阴性乳腺癌 组织桥接整合因子1 Ⅰ型胶原蛋白基因 核转运蛋白基因2(KPNA2) 复发 预测价值 

分 类 号：R737.9[医药卫生—肿瘤]