伴自杀意念的双相障碍Ⅱ型患者局部脑血流灌注特征分析  

Characteristics of regional cerebral blood flow perfusion in patients with type 2 bipolar disorder and suicidal ideation

作　　者：王丽娜 戴伯坚 刘星延 WANG Lina;DAI Bojian;LIU Xingyan(Authors'address:Department of Psychiatry,Wenzhou Seventh People's Hospital,Wenzhou 325000,China)

机构地区：[1]温州市第七人民医院精神科,325000

出　　处：《心电与循环》2024年第3期247-251,共5页Journal of Electrocardiology and Circulation

摘　　要：目的分析伴自杀意念的双相障碍Ⅱ型患者局部脑血流灌注(CBF)临床特征。方法回顾性选择2019年4月至2021年4月在温州市第七人民医院接受治疗的双相障碍Ⅱ型患者100例,根据贝克自杀意念量表19项(BSSI-19)评分分为自杀意念组和无自杀意念组各50例。另选取同期在本院体检的健康志愿者50名作为健康对照组。均行头颅MRI检查,采用Functool软件包对图像进行处理获得CBF图,比较组间CBF差异。分析CBF与认知功能的关系。结果与对照组比较,无自杀意念组与自杀意念组MoCA各认知领域评分及MoCA总分较低(P<0.05),左侧颞上回和左侧壳核CBF较高,自杀意念组的右侧后扣带回和左侧海马旁回CBF较低(均P<0.05)。自杀意念组左侧海马旁回的CBF值与MoCA延迟记忆评分呈正相关(P<0.05)。结论伴自杀意念双相障碍Ⅱ型患者右侧后扣带回和左侧海马旁回CBF明显降低,左侧海马旁回的CBF降低与延迟记忆减退相关。Objective To investigate the characteristics of regional cerebral blood flow(CBF)in patients with type 2 bipolar disorder and suicide ideation.Methods A total of 100 patients with type 2 bipolar disorder who received treatment in Wenzhou Seventh People's Hospital from April 2019 to April 2021 were included.They were divided into non-suicidal ideation group(n=50)and suicidal ideation group(n=50)based on BSSI-19 score.Fifty healthy subjects who underwent physical examination in Wenzhou Seventh People's Hospital at the same time were selected as a control group.Cranial magnetic resonance imaging was performed in all subjects.CBF images were built using Functool package.The CBF was compared among groups.The relation between CBF and cognitive function was analyzed.Results The Montreal cognitive assessment(MoCA)scores in various cognitive domains and MoCA total score were significantly lower in non-suicidal ideation group and suicidal ideation group than in the control group(all P<0.05).Compared with the control group,CBF significantly increased in left superior temporal gyrus and left putamen in suicidal ideation and non-suicidal ideation groups,decreased in right posterior cingulate gyrus and left parahippocampal gyrus in suicidal ideation group(all P<0.05).CBF in left parahippocampal gyrus was positively correlated with delayed memory score in suicidal ideation group(P<0.05).Conclusion CBF decreases in right posterior cingulate gyrus and left parahippocampal gyrus in patients with type 2 bipolar disorder and suicidal ideation.CBF decrease in left parahippocampal gyrus is related to delayed memory impairment.

关 键 词：自杀意念 双相障碍 局部脑血流 

分 类 号：R749.4[医药卫生—神经病学与精神病学]