前列腺癌中自噬性细胞死亡的分子通路和调控机制综述  

Molecular pathways and regulatory mechanisms of autophagic cell death in prostate cancer

作　　者：黄山 喻俊峰 尤祥云 易成 张满 向振东 HUANG Shan;YU Junfeng;YOU Xiangyun;YI Cheng;ZHANG Man;XIANG Zhendong(the First Clinical Medical College of China Three Gorges University,Yichang,Hubei,443002;Department of Urological Surgery,Yichang Central People′s Hospital,Yichang,Hubei,443002;Hubei Provincial Key Laboratory of Tumor Microenvironment and Immunotherapy of China Three Gorges University,Yichang,Hubei,443002;Third-level Laboratory of Chinese Medicine Pharmacology Research of State Administration of Traditional Chinese Medicine of China Three Gorges University,Yichang,Hubei,443002)

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443002 [2]湖北省宜昌市中心人民医院泌尿外科,湖北宜昌443002 [3]三峡大学肿瘤微环境与免疫治疗湖北省重点实验室,湖北宜昌443002 [4]三峡大学国家中医药管理局中药药理科研三级实验室,湖北宜昌443002

出　　处：《实用临床医药杂志》2024年第10期131-135,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(82203408);湖北省自然科学基金项目(2020CFB379);国家中医药管理局中药药理科研三级实验室项目(2023PTCM02)。

摘　　要：前列腺癌(PCa)是全球男性中第2常见的癌症,近年来发病率和致死率均呈快速上升趋势。PCa的发生发展与自噬密切相关,自噬性细胞死亡可促进或抑制PCa细胞的增殖和存活。本文对自噬性细胞死亡抑制PCa进展的分子通路及其相关调控机制进行综述,以期探寻新的PCa治疗方法。Prostate cancer(PCa)is the second most common cancers among men worldwide,with a rapidly increasing trend in incidence and mortality in recent years.The occurrence and development of PCa are closely related to autophagy,and autophagic cell death can promote or inhibit the proliferation and survival of PCa cells.This article reviewed the molecular pathways and related regulatory mechanisms of autophagic cell death inhibiting PCa progression,aiming to explore new PCa treatment methods.

关 键 词：细胞死亡 前列腺癌 线粒体自噬 自噬 信号通路 

分 类 号：R737.25[医药卫生—肿瘤] R697[医药卫生—临床医学] R730.2