重组人表皮生长因子衍生物滴眼液在白内障术后干眼症患者中的应用效果  

The Application Effect of Recombinant Human Epidermal Growth Factor Derivative Eye Drops in Patients with Dry Eye after Cataract Surgery

作　　者：李根 LI Gen(Zhangshu People's Hospital,Zhangshu Jiangxi 331200,China)

机构地区：[1]樟树市人民医院,江西樟树331200

出　　处：《药品评价》2024年第2期216-219,共4页Drug Evaluation

摘　　要：目的 探讨白内障术后干眼症应用重组人表皮生长因子(rhEGF)衍生物滴眼液的疗效。方法 纳入80例樟树市人民医院2020年10月至2022年10月白内障术后干眼症患者作为研究对象,按随机数字表法将其分为两组。对照组(40例)用玻璃酸钠滴眼液,观察组(40例)在对照组基础上加用rhEGF衍生物滴眼液。比较两组临床疗效、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分、泪液分泌实验(SIt)、干眼症状评分、炎性因子平及不良反应。结果 相较于对照组,观察组临床疗效高,有统计学差异(P<0.05)。相较于对照组,观察组治疗后BUT、SIt较高,FL评分、干眼症状评分低,差异有统计学意义(P<0.05);观察组治疗后白介素(IL)-1β、IL-6、肿瘤坏死因子-α(TNF-α)水平低,差异有统计学意义(P<0.05)。组间对比两组不良反应差异无统计学意义(P>0.05)。结论 rhEGF衍生物滴眼液治疗白内障术后干眼症可有效促进角膜愈合,增强泪膜稳定性,减轻眼部炎症,且副作用较小,具有明显的临床应用优势,值得推广。Objective To investigate the therapeutic effect of recombinant human epidermal growth factor(rhEGF)derivative eye drops on dry eye after cataract surgery.Methods 80 patients with dry eye syndrome after cataract surgery in Zhangshu People's Hospital from October 2020 to October 2022 were included as the study subjects and divided into two groups using a random number table method.The control group(40 cases)received sodium hyaluronate eye drops,while the observation group(40 cases)received rhEGF derivative eye drops based on the control group.Compare the clinical efficacy,tear film rupture time(BUT),corneal fluorescence staining(FL)score,tear secretion test(SIt),dry eye symptom score,inflammatory factors,and adverse reactions between the two groups.Results Compared with the control group,the observation group had a higher clinical efficacy with a statistical difference(P<0.05);the observation group had higher BUT and SIt after treatment,lower FL score and dry eye symptom score,with a statistical difference(P<0.05);the observation group had lower interleukin(IL)-1β、IL-6,tumor necrosis factor-α(TNF-α),with statistical differences(P<0.05).There was no difference in adverse reactions between the two groups(P<0.05).Conclusion rhEGF derivative eye drops can effectively promote corneal healing,enhance tear film stability,reduce eye inflammation,and have fewer side effects in the treatment of dry eye after cataract surgery.It has obvious clinical application advantages and is worth promoting.

关 键 词：干眼症 白内障 重组人表皮生长因子衍生物 角膜内皮细胞功能 炎性因子 泪膜稳定性 

分 类 号：R779.66[医药卫生—眼科] R777.34[医药卫生—临床医学]