同源异型盒基因A5、三结构域蛋白14与结直肠癌的关系  

Relationship between HOXA5,TRIM14 and colorectal cancer

作　　者：张胜威[1] 许召杰 王东[1] 王华胜[1] 李晓洁[1] 屈海涛[2] ZHANG Sheng-wei;XU Zhao-jie;WANG Dong;WANG Hua-sheng;LI Xiao-jie;QU Hai-tao(Department of Anorectal Surgery,Zhengzhou People's Hospital,Henan University of Traditional Chinese Medicine,Zhengzhou 450003,Henan,CHINA;Anorectal Disease Diagnosis and Treatment Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,Henan,CHINA)

机构地区：[1]河南中医药大学郑州人民医院肛肠外科,河南郑州450003 [2]河南中医药大学第一附属医院肛肠病诊疗中心,河南郑州450003

出　　处：《海南医学》2024年第12期1673-1678,共6页Hainan Medical Journal

基　　金：2020—2021年度河南省中医药科学研究专项课题项目(编号:20-21ZY2180)。

摘　　要：目的探讨结直肠癌组织同源异型盒基因A5(HOXA5)、三结构域蛋白14(TRIM14)蛋白表达水平与临床病理特征及患者预后的关系。方法回顾性收集整理2016年5月至2018年5月期间于河南中医药大学郑州人民医院确诊的120例结直肠癌患者癌组织及癌旁组织标本及相关临床资料,采用免疫组化法检测组织HOXA5、TRIM14蛋白表达水平;分析HOXA5、TRIM14水平与结直肠癌患者临床病理特征及预后的关系;采用Kaplan-Meier法分析组织中HOXA5、TRIM14表达与结直肠癌5年生存率的关系;采用Cox比例风险回归模型分析结直肠癌5年预后影响因素。结果结直肠癌组织中TRIM14蛋白阳性率为73.33%,明显高于癌旁组织的10.00%,HOXA5蛋白阳性率为27.50%,明显低于癌旁组织的81.67%,差异均有统计学意义(P<0.05)。TRIM1蛋白阳性表达患者肿瘤低分化比例为42.05%,浸润深度T_(3)~T_(4)比例为72.73%,有淋巴结转移比例为47.73%,有远处转移比例为29.55%,明显高于TRIM1蛋白阴性表达的12.50%、37.50%、12.50%、6.25%,差异均有统计学意义(P<0.05);HOXA5蛋白阴性表达患者肿瘤低分化比例为41.38%,浸润深度T3~T4比例为77.01%,有淋巴结转移比例为48.28%,有远处转移比例为29.89%,明显高于HOXA5蛋白阳性表达的15.15%、27.27%、12.12%、6.06%,差异均有统计学意义(P<0.05)。结直肠癌组织中HOXA5阴性表达和TRIM14阳性表达患者的5年生存率分别为57.47%、59.09%,明显低于HOXA5阳性表达患者的90.91%和TRIM14阴性表达患者的87.50%,差异均有统计学意义(P<0.05)。死亡组患者有淋巴结转移比例为85.00%,有远处转移比例为55.00%,明显高于生存组的15.00%、7.50%,差异均有统计学意义(P<0.05)。经Cox比例风险回归模型分析结果显示,TRIM14是结直肠癌患者5年内死亡的独立危险因素,HOXA5是结直肠癌患者5年内死亡的保护因素(P<0.05)。结论结直肠癌组织中TRIM14呈高表达状态,HOXA5呈低表达状态,两者均与TNM分�Objective To investigate the relationship between the expression levels of homeobox gene A5(HOXA5)and tripartite motif-containing 14(TRIM14)in colorectal cancer tissues and their prognosis.Methods The cancer tissue and paracancerous tissue samples and relevant clinical data of 120 patients with colorectal cancer diagnosed in Zhengzhou People's Hospital,Henan University of Traditional Chinese Medicine from May 2016 to May 2018 were collected retrospectively.Immunohistochemical method was applied to detect the expression levels of HOXA5 and TRIM14 proteins in tissues.The relationship between HOXA5,TRIM14 levels and clinical pathological characteristics and prognosis of colorectal cancer patients was analyzed.The relationship between the expression of HOXA5,TRIM14 in tissues and the 5-year survival rate of colorectal cancer was analyzed by Kaplan Meier method.The influencing factors of 5-year prognosis in colorectal cancer was analyzed by Cox proportional hazards regression model.Results The positive rate of TRIM14 protein in colorectal cancer tissue was 73.33%,significantly higher than 10.00%in adjacent tissues;the positive rate of HOXA5 protein was 27.50%,significantly lower than 81.67%in adjacent tissues;the differences were statistically significant(P<0.05).The proportions of poorly differentiated tumors,T3-T4 infiltration depth,lymph node metastasis,distant metastasis were 42.05%,72.73%,47.73%,and 29.55%in patients with positive expression of TRIM1 protein,which were significantly higher than 12.50%,37.50%,12.50%,and 6.25%in patients with negative expression of TRIM1 protein(P<0.05).The proportions of poorly differentiated tumors,T3-T4 infiltration depth,lymph node metastasis,and distant metastasis were 41.38%,77.01%,48.28%,and 29.89%in patients with negative expression of HOXA5 protein,which was significantly higher than 15.15%,27.27%,12.12%,and 6.06%in patients with positive expression of HOXA5 protein(P<0.05).The 5-year survival rate of patients with negative expression of HOXA5 in colorectal cancer tissue w

关 键 词：结直肠癌 同源异型盒基因A5 三结构域蛋白14 预后 临床病理特征 相关性 

分 类 号：R735[医药卫生—肿瘤]