全身低剂量CT骨扫描联合MRI在多发性骨髓瘤诊断、分期及分型中的价值分析  

Value analysis of whole body low-dose CT combined with MRI in diagnosis,staging and classification of multiple myeloma

作　　者：孙洪侠[1] 吴维霞 邢明泉 SUN Hong-xia;WU Wei-xia;XING Ming-quan(Imaging Center,Bozhou People's Hospital,Bozhou Anhui 236800,China;Department of Hematology,Bozhou People's Hospital,Bozhou Anhui 236800,China)

机构地区：[1]亳州市人民医院影像中心,安徽亳州236800 [2]亳州市人民医院血液科,安徽亳州236800

出　　处：《临床和实验医学杂志》2024年第10期1094-1098,共5页Journal of Clinical and Experimental Medicine

基　　金：中国红十字基金会“医学赋能-领航菁英科研项目”(编号:XM-HRYXFN-2021-05-24)。

摘　　要：目的探讨全身低剂量CT骨扫描联合MRI在多发性骨髓瘤诊断、分期及分型中的价值。方法回顾性选择2020年1月至2023年11月来亳州市人民医院诊治的72例多发性骨髓瘤患者病例资料,根据患者自身的疾病特点及相关部位行全身低剂量CT骨扫描、MRI检查。对比全身低剂量CT骨扫描、MRI及二者联合对多发性骨髓瘤、不同部位骨损害病灶的检出率,分析全身低剂量CT骨扫描、MRI与多发性骨髓瘤临床ISS分期的一致性、全身低剂量CT骨扫描、MRI对临床ISS分期的诊断效能,全身低剂量CT骨扫描、MRI与多发性骨髓瘤临床分型的一致性,全身低剂量CT骨扫描、MRI对多发性骨髓瘤临床分型的诊断效能。结果全身低剂量CT骨扫描联合MRI对多发性骨髓瘤的检出率明显较单一检查检出率高,差异有统计学意义(P<0.05)。二者联合对多发性骨髓瘤脊柱骨损害检出率明显较单一检查检出率高,差异有统计学意义(P<0.05);二者联合对颈椎、盆骨、腰椎、四肢及胸椎骨损害的检出率较单一检查高,但组间比较差异无统计意义(P>0.05)。全身低剂量CT与临床ISS分期的Kappa值为0.773(P=0.000),MRI与临床ISS分期的Kappa值为0.719(P=0.000),二者联合与临床ISS分期的Kappa值为0.971(P=0.000),二者联合与ISS分期一致性良好,全身低剂量CT骨扫描、MRI与ISS分期一致性较好。全身低剂量CT骨扫描联合MRI对临床ISS分期Ⅰ期、Ⅱ期的诊断特异度、对Ⅲ期的诊断敏感度明显较单一检查高,差异均有统计学意义(P<0.05);二者联合对Ⅰ期、Ⅱ期的诊断敏感度、对Ⅲ期的诊断特异度较单一诊断高,但组间比较差异无统计学意义(P>0.05)。全身低剂量CT骨扫描与临床分型的Kappa值为0.841,MRI检查与临床分型的Kappa值为0.801,二者联合与临床分型的Kappa值为0.980,CT、MRI及二者联合与临床分型的一致性良好(均P=0.000)。全身低剂量CT骨扫描联合MRI对多发性骨髓瘤临�Objective To investigate the value of whole body low-dose CT combined with MRI in the diagnosis,staging and classification of multiple myeloma.Methods The data of 72 patients with multiple myeloma diagnosed and treated in Bozhou People's Hospital from January 2020 to November 2023 were retrospectively selected,and low-dose CT and MRI examinations of the whole body were performed according to their own disease characteristics and relative sites.The detection rates of systemic low-dose CT,MRI and their combination for multiple myeloma and bone lesions in different parts were compared,the consistency of systemic low-dose CT,MRI and clinical ISS staging of multiple myeloma were analyzed,and the diagnostic efficacy of systemic low-dose CT and MRI for clinical ISS staging were analyzed.Consistency of whole body low-dose CT and MRI with clinical classification of multiple myeloma,diagnostic efficacy of whole body low-dose CT and MRI in clinical classification of multiple myeloma.Results The detection rate of whole body low-dose CT combined with MRI for multiple myeloma was significantly higher than that of single examination,the difference was statistically significant(P<0.05).The detection rate of spinal bone damage in multiple myeloma was significantly higher than that of single examination,the difference was statistically significant(P<0.05);the detection rate of cervical,pelvic,lumbar,limb and thoracic vertebrae was higher than that of single examination,but the difference between groups was not statistically significant(P>0.05).The detection rate of spinal bone damage in multiple myeloma was significantly higher than that of single examination,the difference was statistically significant(P<0.05).The detection rate of bone damage of skull,pelvis,ribs and extremities was higher than that of single examination,but there was no statistically significant difference between groups(P>0.05).Kappa value of whole body low-dose CT and clinical ISS stage was 0.773(P=0.000),Kappa value of MRI and clinical ISS stage was 0.719(P=

关 键 词：全身低剂量CT骨扫描 MRI 多发性骨髓瘤 诊断 分期 分型 

分 类 号：R733.3[医药卫生—肿瘤]