氨苄西林联合羟甲烟胺对慢性胆囊炎患者胆囊功能、氧化应激的影响  

Effects of ampicillin combined with nicotinylmethylamide on gallbladder function and oxidative stress in patients with chronic cholecystitis

作　　者：袁昊 YUAN Hao(Qingshan District Honggangcheng Street Community Health Service Center(Qingshan District First Hospital),Wuhan 430080,China)

机构地区：[1]武汉市青山区红钢城街社区卫生服务中心(青山区第一医院),430080

出　　处：《中国实用医药》2024年第11期117-120,共4页China Practical Medicine

摘　　要：目的 研究氨苄西林联合羟甲烟胺治疗慢性胆囊炎的临床疗效。方法 100例慢性胆囊炎患者,按随机数表法分为对照组与研究组,每组50例。对照组采用氨苄西林治疗,研究组采用氨苄西林联合羟甲烟胺治疗。比较两组临床疗效、症状(腹胀、恶心、右上腹疼痛)缓解时间、不良反应发生率及治疗前后胆囊功能(胆囊容积、胆囊壁厚度、胆囊收缩率)、氧化应激指标[丙二醇(MDA)、谷胱甘肽过氧化物酶(GSH-Px)及超氧化物歧化酶(SOD)]。结果 研究组总有效率相比于对照组更高(96.00%VS 78.00%)(P<0.05)。研究组腹胀、恶心、右上腹疼痛缓解时间分别为(4.48±0.81)、(3.84±0.75)、(5.81±0.62)d,均短于对照组的(5.66±0.73)、(4.89±0.82)、(6.69±0.58)d(P<0.05)。治疗1个月后,两组胆囊容积、胆囊壁厚度均下降,胆囊收缩率上升,且研究组胆囊容积(22.29±2.06)cm3、胆囊壁厚度(2.21±0.54)mm低于对照组的(26.49±1.93)cm3、(3.01±0.57)mm,胆囊收缩率(56.82±3.48)%高于对照组的(46.67±2.85)%(P<0.05)。治疗1个月后,两组MDA较治疗前下降,SOD、GSH-Px较治疗前上升,且研究组MDA(9.75±1.53)nmol/ml低于对照组的(14.69±1.69)nmol/ml,SOD(119.65±6.89)U/ml、GSH-Px(78.75±5.62)U/L高于对照组的(106.53±6.78)U/ml、(66.52±4.82)U/L(P<0.05)。研究组不良反应发生率(8.00%)与对照组(4.00%)相比,无显著差异(P>0.05)。结论 氨苄西林联合羟甲烟胺治疗慢性胆囊炎疗效确切,可有效改善患者胆囊功能,减轻氧化应激,且未明显增加不良反应。Objective To study the clinical efficacy of ampicillin combined with nicotinylmethylamide on gallbladder function and oxidative stress in patients with chronic cholecystitis.Methods 100 cases of chronic cholecystitis were divided into a control group and a study group according to the random number table method,each with 50 cases.The control group was treated with ampicillin,and the study group was treated with ampicillin combined with nicotinylmethylamide.Both groups were compared in terms of clinical efficacy,symptom(abdominal distension,nausea,right upper abdominal pain)relief time,adverse reactions,gallbladder function(gallbladder volume,gallbladder wall thickness,gallbladder contraction rate)and oxidative stress indicators[malondialdehyde(MDA),glutathione peroxidase(GSH-Px),and superoxide dismutase(SOD)]before and after treatment.Results The total effective rate of the study group was higher than that of the control group(96.00%VS 78.00%)(P<0.05).The relief time of abdominal distension,nausea and right upper abdominal pain in the study group were(4.48±0.81),(3.84±0.75)and(5.81±0.62)d,which were shorter than(5.66±0.73),(4.89±0.82)and(6.69±0.58)d in the control group(P<0.05).After 1 month of treatment,the gallbladder volume and gallbladder wall thickness decreased and gallbladder contraction rate increased in both groups compared with those before treatment;the gallbladder volume and gallbladder wall thickness in the study group were(22.29±2.06)cm3 and(2.21±0.54)mm,which were lower than(26.49±1.93)cm3 and(3.01±0.57)mm in the control group;the study group had higher gallbladder contraction rate of(56.82±3.48)%than(46.67±2.85)%in the control group(P<0.05).After 1 month of treatment,MDA decreased,and SOD and GSH-Px increased in both groups compared with those before treatment;the study group had lower MDA of(9.75±1.53)nmol/ml than(14.69±1.69)nmol/ml in the control group;the study group had SOD of(119.65±6.89)U/ml and GSH-Px of(78.75±5.62)U/L,which were higher than(106.53±6.78)U/ml and(66.52±4.82

关 键 词：慢性胆囊炎 羟甲烟胺 氨苄西林 胆囊功能 氧化应激 

分 类 号：R575.61[医药卫生—消化系统]