儿童龋病与口腔幽门螺杆菌及唾液微量元素的相关性  

The correlation between childhood caries and oral Helicobacter pylori and saliva trace elements

作　　者：张建军 谢桂英 ZHANG Jian-Jun;XIE Gui-ying(Department of Stomatology,Xiangyang Stomatological Hospital,Hubei Xiangyang 441003,China;Xiling Hospital of Stomatology,Hubei Yichang 443000,China)

机构地区：[1]襄阳市口腔医院口腔预防科,湖北襄阳441003 [2]宜昌市西陵口腔医院,湖北宜昌443000

出　　处：《临床口腔医学杂志》2024年第5期297-300,共4页Journal of Clinical Stomatology

摘　　要：目的:分析口腔幽门螺杆菌(Helicobacter pylori,HP)感染、唾液微量元素与儿童龋病的关系。方法:选取我院2021年2月~2023年3月收治的龋病患儿124例为研究组,另选同时段因其他原因就诊的124例非龋病患儿为对照组。两组患儿均进行口腔幽门螺杆菌、唾液pH值及钠、钙、钾、氟含量检测。比较患儿HP阳性占比及HP-DNA拷贝数、唾液pH值及钠、钙、钾、氟、一氧化氮(nitric oxide,NO)含量。采用Spearman相关性分析HP-DNA拷贝数与唾液微量元素及与龋病病情的相关性。结果:D5 HP-DNA拷贝数、HP阳性占比>D4>D3>D2>D1,差异有统计学意义(P<0.05)。研究组NO水平大于对照组,pH值小对照组(P<0.05);NO水平D5>D4>D3>D2,pH值D5<D4<D3<D2,差异有统计学意义(P<0.05)。HP-DNA拷贝数与NO水平呈正相关,与pH值呈负相关性(P<0.05)。龋病病情与HP-DNA拷贝数、NO水平呈正相关,与pH值呈负相关性(P<0.05)。结论:儿童龋病患者存在不同程度HP感染以及唾液微量元素及pH改变,龋病病情与HP-DNA拷贝数、NO水平呈正相关,与唾液pH值呈负相关性。Objective:To analyzes the relationship between oral Helicobacter pylori(HP)infection,saliva trace ele-ments,and childhood caries.Methods:A total of 124 children with dental caries admitted to our hospital from February 2021 to March 2023 were selected as the study group,and 124 non-caries children who were treated for other reasons during the same period were selected as the control group.Oral Helicobacter pylori,saliva pH,sodium,calcium,potassium and fluorine were detected in both groups.The HP-positive proportion,DNA copy number of HP,saliva pH and the content of sodium,cal-cium,potassium,fluorine and nitric oxide(NO)in the children were compared.Spearman correlation analysis was used to as-sess the correlation between the severity of dental caries and oral HP infection,trace elements in saliva.Results:The copy number of D5 HP-DNA and the proportion of HP positivity>D4>D3>D2>D1 showed statistically significant differences(P<0.05).The NO level in the study group was higher than that in the control group,and the pH value was lower in the control group(P<0.05);NO levels D5>D4>D3>D2,pH values D5<D4<D3<D2,differences statistically significant(P<0.05).The copy number of HP-DNA was positively correlated with NO level,negatively correlated with pH value(P<0.05).The condi-tion of dental caries was positively correlated with HP-DNA copy number,NO level,negatively correlated with pH value(P<0.05).Conclusion:Children with dental caries have varying degrees of HP infection and changes in trace elements in saliva and saliva pH,as well as the condition of dental caries was positively correlated with HP-DNA copy number,NO level,nega-tively correlated with saliva pH.

关 键 词：口腔幽门螺杆菌感染 唾液微量元素 唾液PH值 龋病 相关性 

分 类 号：R781.1[医药卫生—口腔医学]