半夏泻心汤治疗化疗性肠黏膜炎的治疗效果分析  

Analysis of therapeutic effect of Banxia Xiexin Decoction on chemotherapeutic intestinal mucositis

作　　者：张西洁[1] Zhang Xijie(The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Henan,Zhengzhou,450000,China)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450000

出　　处：《生命科学仪器》2024年第1期205-207,共3页Life Science Instruments

摘　　要：目的:分析化疗性肠黏膜炎治疗中半夏泻心汤的治疗效果。方法:回顾性选取2020年2月-2023年2月本院化疗性肠黏膜炎患者100例,依据用药方法分为半夏泻心汤组、洛哌丁胺组两组,各50例。统计分析两组中医症候积分、肠道菌群相对丰度、肠黏膜屏障功能、血清炎症细胞因子水平、临床疗效、腹泻发生情况。结果:半夏泻心汤组患者的大便泄泻、腹痛腹胀、口干口苦、食欲不振、倦怠乏力、畏寒积分及中医症候总积分、肠球菌、肠杆菌、D-乳酸、ET、DAO、TNF-α、IL-1β、IL-6水平均低于洛哌丁胺组(P<0.05),乳酸杆菌、双歧杆菌、IL-10水平均高于洛哌丁胺组(P<0.05)。半夏泻心汤组患者的总有效率90.00%(45/50)高于洛哌丁胺组62.00%(31/50)(χ^(2)=10.746,P<0.05)。半夏泻心汤组患者的腹泻发生率6.00%(3/50)低于洛哌丁胺组50.00%(25/50)(χ^(2)=24.008,P<0.05)。结论:化疗性肠黏膜炎治疗中半夏泻心汤的治疗效果较洛哌丁胺好。Objective:To analyze the therapeutic effect of Banxia Xingxin decoction in the treatment of chemotherapeutic intestinal mucositis.Methods:A total of 100 patients with chemotherapeutic intestinal mucositis in our hospital from February 2020 to February 2023 were retrospectively enrolled,and they were divided into two groups,Banxia Xingxin decoction group and loperamide group,with 50 cases in each group.The TCM syndrome score,relative abundance of intestinal flora,intestinal mucosal barrier function,serum inflammatory cytokine level,clinical efficacy,and diarrhea occurrence of the two groups were statistically analyzed.Results:The levels of fecal diarrhea,abdominal pain,abdominal distention,dry mouth and bitter mouth,loss of appetite,fatigue,chills and total TCM syndrome scores,enterococci,enterobacteriaceae,D-lactic acid,ET,DAO,TNF-α,IL-1βand IL-6 in the Banxia Xingxin decoction group were lower than those in the loperamide group(P<0.05),and the levels of lactobacillus,bifidobacteria and IL-10 were higher than those in the loperamide group(P<0.05).The total effective rate of the patients in the Banxia Xingxin decoction group was 90.00%(45/50),which was higher than that in the loperamide group 62.00%(31/50)(χ^(2)=10.746,P<0.05).The incidence of diarrhea in the Banxia Xingxin decoction group was 6.00%(3/50),which was lower than that in the loperamide group 50.00%(25/50)(χ^(2)=24.008,P<0.05).Conclusion:In the treatment of chemotherapeutic intestinal mucositis,the therapeutic effect of Banxia Xingxin decoction is better than that of loperamide.

关 键 词：化疗性肠黏膜炎 半夏泻心汤 中医症候积分 肠道菌群相对丰度 肠黏膜屏障功能 炎症细胞因子 腹泻 

分 类 号：R574[医药卫生—消化系统]