白藜芦醇延缓皮肤衰老的作用功效及应用研究进展  

Research progress in the efficacy and application of resveratrol on delaying skin aging

作　　者：石径 姜燕飞 赵春月 SHI Jing;JIANG Yanfei;ZHAO Chunyue(Beijing Qingyan Boshi Health Management Co.,Ltd.,Beijing 100085,China)

机构地区：[1]北京青颜博识健康管理有限公司,北京100085

出　　处：《轻工学报》2024年第3期119-126,共8页Journal of Light Industry

基　　金：北京市科技新星计划创业新星项目(20220484186)。

摘　　要：在简要概述白藜芦醇理化特性和来源的基础上,从抗皮肤光老化、抗皮肤氧化、抗皮肤色素沉着和抗皮肤皱纹4个方面,对白藜芦醇在延缓皮肤衰老方面的作用功效及其在化妆品应用中的研究进展进行综述。指出,白藜芦醇具有显著的抗皮肤衰老功效,并已在众多动物实验和临床实验研究中得到证实;在化妆品领域,白藜芦醇不仅以其保湿、紧致皮肤、美白及抗皱等多重抗衰老特性广泛应用于面霜、乳液及精华等多种产品剂型中,而且通过纳米脂质体系统对其进行包埋和递送,可以有效改善它的透皮渗透能力,进而提升其整体的护肤效果;然而,白藜芦醇仍存在稳定性较差、生物利用度低和高剂量口服具有一定毒性等问题,限制了其在化妆品中的更广泛应用。因此,未来还需对白藜芦醇进行全面科学的剂量研究和安全性评价,同时也需要开展更多的临床研究来验证其效果并推动其应用,从而为白藜芦醇作为化妆品和美容类产品中具有抗皮肤衰老的功能活性成分的开发和应用提供参考。On the basis of a brief overview of the physicochemical properties and sources of resveratrol,this research reviewed the research progress of resveratrol in delaying skin aging and its application in cosmetics from four aspects:anti-skin photoaging,anti-skin oxidation,anti-skin pigmentation,and anti-skin wrinkles.It was pointed out that resveratrol had significant anti-aging effects on the skin and had been confirmed in numerous animal tests and clinical trials;In the cosmetics field,resveratrol was widely applied in various product formulations such as face creams,lotions and essence due to its multiple anti-aging properties such as moisturizing,firming,whitening,and anti-wrinkle effects.The encapsulation and delivery of resveratrol through a nanoliposome system could effectively improve its transdermal permeability and enhance its overall skincare effect;However,resveratrol still had problems such as poor stability,low bioavailability,and certain toxicity at high dose oral administration,which limited its wider application in cosmetics.In the future,comprehensive scientific dosage studies and safety evaluation of resveratrol are needed,and more clinical studies are also needed to verify the effectiveness and promote the application of resveratrol.These will provide reference for the development and application of resveratrol as a functional active ingredient with anti-against skin aging properties in cosmetics and beauty products.

关 键 词：白藜芦醇 延缓皮肤衰老 抗皮肤光老化 抗皮肤氧化 抗皮肤色素沉着 抗皮肤皱纹 

分 类 号：TQ658[化学工程—精细化工] TS201[轻工技术与工程—食品科学]