白花蛇舌草-半枝莲药对治疗胃癌的物质基础和作用机制研究进展  

Research progress on material basis and mechanism of Hedyotis Diffusa-Scutellaria Barbata Herb Pair in the treatment of gastric cancer

作　　者：张晓威 王楠 代梦格 刘瑞娟 马亭 ZHANG Xiaowei;WANG Nan;DAI Mengge;LIU Ruijuan;MA Ting(School of Pharmacy,Zhengzhou University,Zhengzhou 450001,Henan,China;Department of Pharmacy,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan,China)

机构地区：[1]郑州大学药学院,河南郑州450001 [2]郑州大学第一附属医院药学部,河南郑州450052

出　　处：《中国临床药理学与治疗学》2024年第7期831-840,共10页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：河南省科技研发计划联合基金(232301420058)。

摘　　要：胃癌是消化系统的常见恶性肿瘤之一,好发于中老年人群。中医认为胃癌是由津亏热结、癌毒胶结于胃腹而形成的一种瘤瘕,在临床中常用清热解毒类药物进行治疗。白花蛇舌草-半枝莲药对具有清热解毒、活血化瘀、消痈散结、抗炎止痛的作用,可治疗胃癌。现代药理学研究证实,白花蛇舌草-半枝莲药对可通过诱导细胞凋亡、抑制细胞增殖、抑制血管生成、改善免疫微环境、下调端粒酶活性等途径起到抗胃癌的作用。本文对白花蛇舌草-半枝莲药对配伍后活性成分抗胃癌的机制进行综述,为白花蛇舌草-半枝莲药对的临床用药和抗胃癌新药研发提供理论依据和参考。Gastric cancer is one of the most common malignant tumors in the digestive system,which often occurs in middle-aged and elderly people.Traditional Chinese medicine recognizes gastric cancer as a kind of tumor characterized by fluid deficiency,heat accumulation and the growing binding of toxins in the stomach.It is commonly treated with heat-clearing and detoxifying drugs in clinical practice.Hedyotis diffusa-Scutellaria barbata herb pair(HS)has the effects of clearing heat and detoxifying,promoting blood circulation,resolving carbuncle and expulsing boil,anti-inflammatory and analgesic,which are consistent with the etiology and pathogenesis of gastric cancer,therefore,it can be used for the treatment of gastric cancer.Modern pharmacological researches have confirmed that HS can play an anti-gastric cancer role by inducing cell apoptosis,inhibiting cell proliferation,inhibiting angiogenesis,improving immune microenvironment and down-regulating telomerase activity.Herein,this review summarizes the active ingredients and related mechanism responsible for the anti-gastric cancer effect of HS,which will provide the theoretical basis for its clinical use and the development of new drugs against gastric cancers.

关 键 词：白花蛇舌草 半枝莲 药对 胃癌 药理机制 

分 类 号：R735.2[医药卫生—肿瘤]