内皮细胞Piezo1调控H型血管生成在骨质疏松症病理机制中的意义  

Significance of Piezo1 of endothelial cells in regulating type H vessels in the pathogenesis of osteoporosis

作　　者：张华[1] 何琪 杨均政 陈柏豪 陈楚仪 池伟进 潘兆丰 肖嘉聪 黎淼 黎少聪 林跃玮 王璠琛 王薪添 曾嘉旭 王海彬[2] 孟凯[3] 陈鹏[2] ZHANG Hua;HE Qi;YANG Junzheng;CHEN Bohao;CHEN Chuyi;CHI Weijin;PAN Zhaofeng;XIAO Jiacong;LI Miao;LI Shaocong;LIN Yuewei;WANG Panshen;WANG Xintian;ZENG Jiaxu;WANG Haibin;MENG Kai;CHEN Peng(The First Clinical School of Guangzhou University of Chinese Medicine,Guangzhou 510405;Department of Orthopedics,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405;Department of Orthopedics,Shandong University of Traditional Chinese Medicine Affiliated Hospital,Ji’nan 250014,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州中医药大学第一附属医院骨科,广东广州510405 [3]山东中医药大学附属医院骨科,山东济南250014

出　　处：《中国骨质疏松杂志》2024年第6期875-879,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(82374470)。

摘　　要：内皮细胞(endothelial cells,ECs)缺失Piezo1不仅能影响骨重塑导致骨量丢失、加重骨质疏松症,而且能引起H型血管的减少;H型血管调控的成骨-成血管偶联失衡在骨质疏松症的发病过程中起到关键作用。Piezo1为治疗骨质疏松症提供了分子层面的新思路和新视角。笔者主要对Piezo1蛋白介导的H型血管生成的机制作一综述,总结近年来关于骨质疏松症及内皮细胞Piezo1的最新研究进展,为骨质疏松症的治疗提供新的临床见解和理论依据。The loss of Piezo1 of endothelial cells(ECs)not only affects bone remodeling,leading to bone loss and aggravating OP,but also causes the decrease of Type H Vessels.The imbalance of osteogenic-angiogenic coupling regulated by Type H Vessels plays an important role in the pathogenesis of OP.Piezo1 offers new ideas and perspectives at the molecular level for treating osteoporosis.This article mainly reviews the mechanism of Piezo1 mediated Type H Vessels in OP treatment and summarizes the latest research advance of Piezo1 on osteoporosis and endothelial cells,providing theoretical basis for clinical treatment of osteoporosis.

关 键 词：内皮细胞 Piezo1 骨质疏松症 H型血管 

分 类 号：R363[医药卫生—病理学] R589.5[医药卫生—基础医学]