中心性肥胖对乳腺癌发生风险的影响及膳食因素作用  

The impact of central obesity on breast cancer risk and the significance of dietary factors

作　　者：张玉 李春微 王永超 包媛媛 李琦[2] 李霖[2] 庞毅[2] 郭春利[2] 范昱辰 孟祥朝[2] 于康 Zhang Yu;Li Chunwei;Wang Yongchao;Bao Yuanyuan;Li Qi;Li Lin;Pang Yi;Guo Chunli;Fan Yuchen;Meng Xiangchao;Yu Kang(Department of Clinical Nutrition&Health Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,and Peking Union Medical College,Beijing 100730,China;Department of Thyroid,Breast,Hernia,and Abdominal Wall surgery,The Third Central Hospital of Tianjin,Tianjin 300170,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院临床营养科,北京100730 [2]天津市第三中心医院甲乳疝腹壁外科,天津300170

出　　处：《中华临床营养杂志》2024年第2期65-70,共6页Chinese Journal of Clinical Nutrition

基　　金：中央高水平医院临床科研业务费(2022-PUMCH-B-055);全民营养科研基金(CNS-NNSRG2021-129)。

摘　　要：目的探讨中心性肥胖对乳腺癌发生风险的影响,以及膳食相关影响因素可能起到的促进或抑制作用。方法病例对照研究,共纳入212例研究对象,包括63例初治乳腺癌患者,71例乳腺结节患者,以及78例健康女性作为对照组。使用生物电阻抗分析测量人体成分,并使用食物频率法调查受试者膳食摄入特征。结果内脏脂肪(OR 1.03,95%CI 1.003~1.077)和躯干脂肪(OR 1.470,95%CI 1.104~2.184)与乳腺癌的风险增加独立相关。以低豆类和乳制品摄入为特征(OR 1.300,95%CI 1.044~1.619)和以高谷物和红肉摄入为特征(OR 2.254,95%CI 1.705~2.982)的膳食模式会增加患乳腺癌的风险,其中高肉类摄入(β0.268,95%CI 0.034~0.503)和豆类摄入(β-0.485,95%CI-0.865~-0.104)可分别促进和抑制内脏脂肪的累积。结论中心性肥胖是乳腺癌的独立危险因素,膳食豆类摄入不足以及红肉摄入过高可进一步促进乳腺癌患者的中心性肥胖。Objective To explore the influence of central obesity on the risk of breast cancer and the possible role of dietary factors in its prevention.Methods This study is a case-control study including a total of 212 participants,of whom 63 were with breast cancer,71 were with breast nodules,and 80 were healthy controls.We used bioelectrical impedance analysis to measure body composition,and adopted the food frequency questionnaire to investigate dietary intake of participants.Results The visceral adipose tissue(OR=1.03,95%CI:1.003 to 1.077)and trunk fat mass(OR=1.470,95%CI:1.104 to 2.184)were independently associated with the increased risk of breast cancer.Dietary patterns characterized by low dietary intake of beans and dairy products(OR=1.300,95%CI:1.044 to 1.619)and high intake of cereals and red meat(OR=2.254,95%CI:1.705 to 2.982)will increase the risk of breast cancer.Moreover,high meat intake(β=0.268,95%CI:0.034 to 0.503)would advance the accumulation of visceral fat,while high bean intake(β=-0.485,95%CI:-0.865 to-0.104)would inhibit.Conclusions Central obesity is an independent risk factor for breast cancer.Insufficient intake of beans and excessive intake of red meat are identified as factors that can exacerbate central obesity in breast cancer patients.

关 键 词：乳腺癌 中心性肥胖 膳食因素 

分 类 号：R737.9[医药卫生—肿瘤]