牙周组织SOCS6、RORA表达水平对牙周炎患者的预后价值  

Prognostic value of SOCS6 and RORA expression in periodontal tissues in patients with periodontitis

作　　者：王惠 杜启雪 张若君 柏扬[2] WANG Hui;DU Qixue;ZHANG Ruojun;BAI Yang(Department of Stomatology,Guang′anmen Hospital Jinan Hospital/Jinan Hospital of Traditional Chinese Medicine,Jinan,Shandong 250012,China;Department of Pentacenter,the First People′s Hospital of Jinan,Jinan,Shandong 250013,China)

机构地区：[1]广安门医院济南医院/济南市中医医院口腔科,山东济南250012 [2]济南市第一人民医院五官科,山东济南250013

出　　处：《国际检验医学杂志》2024年第12期1501-1505,1510,共6页International Journal of Laboratory Medicine

摘　　要：目的探讨细胞因子信号转导抑制因子6(SOCS6)和维甲酸受体相关孤核受体A(RORA)在牙周炎患者牙周组织中的表达,并分析二者对患者的预后价值。方法选取2021年7月至2023年1月在济南市中医医院接受治疗的224例牙周炎患者作为研究组,另选取224例到济南市中医医院门诊因正畸治疗需要拔除健康牙齿的患者作为对照组。收集其牙周组织并采用实时荧光定量PCR检测牙周组织中SOCS6、RORA表达水平。对牙周炎患者随访3个月,根据随访结果将其分为预后良好组(148例)与预后不良组(76例)。采用多因素Logistic回归分析牙周炎患者预后不良的影响因素,采用受试者工作特征(ROC)曲线分析牙周组织SOCS6、RORA表达水平对牙周炎患者预后不良的预测价值。结果与对照组比较,研究组牙周组织SOCS6、RORA表达水平均降低(P<0.05)。224例牙周炎患者均完成随访,预后不良发生率为33.93%(76/224)。预后不良组牙周组织SOCS6、RORA表达水平均低于预后良好组(P<0.05)。多因素Logistic回归分析显示,患牙位于下颌、患牙为前牙、患牙最深探诊深度、牙周炎严重程度为重度、根形态异常、牙槽骨高度、平均附着丧失均是导致牙周炎患者预后不良的危险因素(P<0.05),牙周组织SOCS6、RORA表达水平均是保护因素(P<0.05)。牙周组织SOCS6、RORA单独预测牙周炎患者预后不良的曲线下面积(AUC)分别为0.833、0.829,二者联合预测的AUC(0.914)高于SOCS6与RORA单独预测(Z=3.659、3.408,P<0.001)。结论牙周炎预后不良患者牙周组织SOCS6、RORA表达水平均降低,二者均对牙周炎患者预后不良具有一定预测效能,且二者联合预测的效果更优。Objective To explore the signal transduction of suppressor of cytokine signaling 6(SOCS6)and retinoic acid receptor related orphan nuclear receptor A(RORA)in patients with periodontitis expression of periodontal tissue,and analyze the prognosis of the patients with value.Methods A total of 224 patients with periodontitis who were treated in Jinan Hospital of Traditional Chinese Medicine from July 2021 to January 2023 were selected as the study group,and 224 patients who needed to extract healthy teeth due to orthodontic treatment to the Jinan Hospital of Traditional Chinese Medicine outpatient were selected as the control group.The periodontal tissues were collected and the expression levels of SOCS6 and RORA in periodontal tissues were detected by real-time fluorescent quantitative PCR.The patients with periodontitis were followed up for 3 months,and according to the follow-up results,they were divided into good prognosis group(148 cases)and poor prognosis group(76 cases).Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with periodontitis.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of SOCS6 and RORA expression levels in periodontal tissues for poor prognosis in patients with periodontitis.Results Compared with the control group,the expression levels of SOCS6 and RORA in the periodontal tissue of the study group were decreased(P<0.05).A total of 224 patients with periodontitis were complete follow-up,the incidence of poor prognosis was 33.93%(76/224).The expression levels of SOCS6 and RORA in periodontal tissues of the poor prognosis group were lower than those of the good prognosis group(P<0.05).Multivariate Logistic regression analysis showed that the affected tooth located in the lower jaw,the affected tooth in the anterior teeth,the deepest probing depth of the affected tooth,the severity of periodontitis,the abnormal root morphology,the alveolar bone height,and the average attachment loss were the risk

关 键 词：牙周炎 细胞因子信号转导抑制因子6 维甲酸受体相关孤核受体A 

分 类 号：R781.4[医药卫生—口腔医学]