膳食脂肪摄入与多囊卵巢综合征风险的关联  

Association between dietary fat intake and risk of polycystic ovary syndrome

作　　者：张雪云 王春艳[2] 程静娴 吴炫烨 王婕妤 罗桂英 Zhang Xueyun;Wang Chunyan;Cheng Jingxian;Wu Xuanye;Wang Jieyu;Luo Guiying(School of Nursing,Anhui Medical University,Hefei 230032,China;Reproductive Center,the First Affiliated Hospital of AnhuiMedical University,Hefei 230000,China)

机构地区：[1]安徽医科大学护理学院,合肥230032 [2]安徽医科大学第一附属医院生殖中心,合肥230000

出　　处：《卫生研究》2024年第3期389-395,共7页Journal of Hygiene Research

基　　金：安徽省高校自然科学研究项目(No.KJ2020A0203);安徽省高校人文社会科学研究项目(No.SK2020A0146);安徽医科大学护理学院研究生青苗培育项目(No.hlqm12023056)。

摘　　要：目的分析膳食脂肪摄入与多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患病风险的关联。方法选取2021年10月至2022年10月于安徽省某三甲医院就诊的PCOS患者为病例组,另选取同时期在该院就诊的非PCOS患者为对照组;共纳入262名研究对象,符合要求的病例组和对照组各纳入131名。采用半定量膳食频率调查问卷对过去一年的膳食摄入情况进行调查,根据食物摄入情况计算各类脂肪酸日均摄入量及脂肪酸供能比。采用Logistic回归分析探讨膳食脂肪摄入与PCOS患病风险的关联。结果PCOS患者膳食总脂肪、脂肪酸、饱和脂肪酸、单不饱和脂肪酸的摄入量均高于对照组(P>0.05),两组二十碳五烯酸日均摄入量差异有统计学意义(P<0.05)。在调整了长期居住地、职业、家庭人均月收入、月经周期是否规律、月经量、减肥经历后,经过Logistic回归分析显示,脂肪供能比与PCOS患病风险呈正相关(OR=1.622,95%CI 1.237~2.127);而单不饱和脂肪酸供能比(OR=0.597,95%CI 0.373~0.955)、多不饱和脂肪酸供能比(OR=0.585,95%CI 0.372~0.921)均与PCOS患病风险呈负相关(P<0.05)。结论脂肪供能比与PCOS患病风险呈正相关,而单不饱和脂肪酸供能比、多不饱和脂肪酸供能比均与PCOS患病风险呈负相关。OBJECTIVE To analyze the association between dietary fat intake and the risk of polycystic ovarian syndrome(PCOS).METHODS PCOS patients treated in a tertiary hospital in Anhui Province from October 2021 to October 2022 were selected as the case group,and non-PCOS patients treated in the hospital during the same period were selected as the control group.A total of 262 subjects were included in the study,131 were included in the case group and 131 in the control group.A semi-quantitative dietary frequency questionnaire was used to investigate the dietary intake in the past year,and the daily intake of various fatty acids and the ratio of fatty acid energy supply were calculated according to the food intake.Logistic regression analysis was used to investigate the association between dietary fat intake and the risk of PCOS.RESULTS The dietary intakes of total fat,fatty acid,saturated fatty acid and monounsaturated fatty acid in PCOS patients were higher than those in control group(P>0.05),and there was statistical significance in daily intakes of eicosapentaenoic acid between two groups(P<0.05).After adjusting for confounding factors such as long-term residence,occupation,family per capita monthly income,menstrual cycle regularity,menstrual volume,and weight loss experience,Logistic regression analysis showed that the ratio of fat supply to energy was positively correlated with the risk of PCOS(OR=1.622,95%CI 1.237-2.127).The energy supply ratio of monosaturated fatty acids(OR=0.597,95%CI 0.373-0.955)and polyunsaturated fatty acids(OR=0.585,95%CI 0.372-0.921)were negatively correlated with the risk of PCOS(P<0.05).CONCLUSION The energy supply ratio of fat was positively correlated with the risk of PCOS,while the energy supply ratio of monosaturated fatty acids and the energy supply ratio of polyunsaturated fatty acids were negatively correlated with the risk of PCOS.

关 键 词：多囊卵巢综合征 膳食脂肪 脂肪酸 

分 类 号：R711.75[医药卫生—妇产科学] R153.1[医药卫生—临床医学]