精神分裂症代谢指标与工作记忆相关性研究  

Study on the correlation between metabolic index and working memory in schizophrenia

作　　者：李君伟 朱文礼 米权慧 宋传福 LI Jun-wei;ZHU Wen-li;MI Quan-hui;SONG Chuan-fu(Department of Psychiatry,The Fourth People’s Hospital of Bengbu Medical College,Wuhu 241000,China)

机构地区：[1]蚌埠医科大学附属芜湖市第四人民医院,241002 [2]首都医科大学附属北京安定医院芜湖医院

出　　处：《临床精神医学杂志》2024年第3期207-210,共4页Journal of Clinical Psychiatry

基　　金：教育部重点实验室开放课题(2021GDN01)。

摘　　要：目的:探索精神分裂症患者代谢指标与工作记忆间的相关性。方法:测量47例入院1周内使用利培酮治疗的精神分裂症患者体质量(weight, WT)、空腹血糖(glucose, GLU)、三酰甘油(triglycerides, TG)、高密度脂蛋白(high density lipoprotein, HDL)、腹壁脂肪厚度,使用阳性和阴性症状量表(positive and negative syndrome scale, PANSS)评定精神症状,运用N-back工作记忆测验精神分裂症患者工作记忆。治疗6个月后再次测量WT、GLU、TG、HDL、腹壁脂肪厚度、评定精神症状、测验工作记忆,进行前后对照,并结合一般资料问卷所得结果进行分析。结果:治疗后WT、TG、腹壁脂肪厚度、药物剂量明显高于治疗前,HDL、PANSS明显低于治疗前,差异均有统计学意义(P均<0.05);1-back.RT(反应时)、2-back.RT明显高于治疗前,差异均有统计学意义(P均<0.05);三酰甘油差值与1-back.RT差值呈正相关(r=0.353,P<0.05),腹壁脂肪厚度差值与1-back.RT差值呈正相关(r=0.322,P<0.05)。结论:精神分裂症患者三酰甘油、腹壁脂肪厚度与工作记忆存在一定相关性,通过控制甘油三脂水平及腹壁脂肪厚度,可能会改善患者工作记忆。Objective:To explore the correlation between metabolic index and working memory in patients with schizophrenia.Method:The Body Weight(WT),Fasting Blood Glucose(GLU),Triglyceride(TG),High Density Lipoprotein(HDL)and abdominal wall fat thickness of 47 patients with schizophrenia treated with risperidone within one week after admission were measured.The Positive and Negative Symptom Scale(PANSS)was used to assess the mental symptoms.Working memory test of schizophrenic patients using N-back working memory.After 6 months of treatment,WT,GLU,TG,HDL,abdominal fat thickness,mental symptoms and working memory were measured again.Before and after the treatment,the results of general data questionnaire were analyzed.Results:After treatment,WT,TG,abdominal wall fat thickness and drug dose were significantly higher than before treatment,while HDL and PANSS were significantly lower than before treatment,with statistical significance(P<0.05).1-back.RT(reaction time),2-back.RT were significantly higher than before treatment,the difference was statistically significant(P<0.05);The difference of triglyceride was positively correlated with the difference of 1-back.RT(r=0.353,P<0.05),and the difference of abdominal wall fat was positively correlated with the difference of 1-back.RT(r=0.322,P<0.05).Conclusion:Triglyceride and abdominal wall fat thickness may be correlated with working memory in patients with schizophrenia,Controlling the level of triglyceride and abdominal fat thickness may improve the working memory of patients.

关 键 词：精神分裂症 代谢指标 工作记忆 

分 类 号：R749.3[医药卫生—神经病学与精神病学]