外阴棘层松解型鳞状细胞癌一例  

Vulvar Acantholytic Squamous Cell Carcinoma:A Case Report

作　　者：刘思敏 魏佳 万怡 李钰滋 杨永秀[2] LIU Si-min;WEI Jia;WAN Yi;LI Yu-zi;YANG Yong-xiu(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Obstetrics and Gynecology,The First Hospital of Lanzhou University,Key Laboratory of Gynecologic Oncology of Gansu Province,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,730000 [2]兰州大学第一医院妇产科,甘肃省妇科肿瘤重点实验室

出　　处：《国际妇产科学杂志》2024年第3期267-270,共4页Journal of International Obstetrics and Gynecology

摘　　要：棘层松解型鳞状细胞癌(acantholytic squamous cell carcinoma,ASCC)是鳞状细胞癌的一种少见的组织学特征变体,外阴ASCC是一个罕见的非典型部位的组织变异,常呈棘层溶解,具有独特的形态学特点,其具体发病机制及病因未明。由于发病率极低,妇科医生普遍对其认识不足,易造成漏诊和误诊。现报告1例79岁原发性外阴ASCC的病例资料,患者因自觉外阴瘙痒5年就诊,妇科检查发现左侧外阴8 cm×4 cm红肿溃疡伴部分白色变,病理活检示符合ASCC,经25次根治性放疗后,建议密切随诊,现放疗结束后3个月余,未见肿瘤复发和转移。国内外关于外阴ASCC的研究报道较少,通过报道该例老年女性外阴ASCC,并分析其临床特征、发病机制、发病因素、鉴别诊断、治疗及预后,以期为ASCC的临床诊疗提供参考。Acantholytic squamous cell carcinoma(ASCC)is a rare histological variant of squamous cell carcinoma,with vulvar ASCC being an uncommon and atypical tissue variant characterized by acantholysis and unique morphological features.Its specific pathogenesis and etiology remain unclear.Given its low incidence,gynecologists generally lack understanding of it,raising the risk of misdiagnosis or missed diagnosis.We report the data of a 79-year-old patient with primary vulvar ASCC,who was admitted to our hospital due to self-reported vulvar pruritus for 5 years.Examination revealed an 8 cm×4 cm red and swollen ulcer on the left vulva with partial white change,and the pathological biopsy showed ASCC.Following 25 times of radical radiotherapy,close follow-up is recommended.And now three months post-radiotherapy,there is no evidence of tumor recurrence or metastasis.There are few research reports on vulvar ASCC both domestically and internationally.This article presents a case of vulvar ASCC in an elderly woman,analyzing its clinical characteristics,pathogenesis,pathogenic factors,differential diagnosis,treatment,and prognosis,in order to provide reference for the clinical diagnosis and treatment of ASCC.

关 键 词：外阴肿瘤 棘层松解型鳞状细胞癌 诊断 鉴别 治疗 预后 病例报告 

分 类 号：R737.35[医药卫生—肿瘤]