血清中载脂蛋白E、sST2及游离脂肪酸水平对急性缺血性脑卒中患者病情转归的预测价值  

Predictive value of serum levels of apolipoprotein E,SST2 and free fatty acids in patients with acute ischemic stroke

作　　者：张倩倩[1] 赵炎葱[1] 马改玲 Zhang Qian-qian;Zhao Yan-cong;Ma Gai-ling(Department of Medical Laboratory,Th First Affiliated Hospital of Henan University,Kaifeng 475099,Henan,China;Kaifeng Kangnuo Pharmaceutical Co,Ltd,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学第一附属医院医学检验科,河南开封475099 [2]开封康诺药业有限公司质量保证部,河南开封475000

出　　处：《四川生理科学杂志》2024年第6期1190-1192,共3页Sichuan Journal of Physiological Sciences

基　　金：开封市科技发展计划项目(编号:1403132)。

摘　　要：目的:探究血清中载脂蛋白E(Apolipoprotein E,ApoE)、可溶性的生长刺激表达基因2蛋白(Soluble growth stimulation expressed gene 2,sST2)及游离脂肪酸(Free fatty acid,FFA)水平对急性缺血性脑卒中患者病情转归的预测价值。方法:选取本院2020年1月至2022年12月神经内科收治的163例急性缺血性脑卒中(Acute ischemic stroke,AIS)患者作为研究对象,根据发病后90 d的转归情况分成转归良好组和转归不良组。收集患者的基线资料;检测对比两组患者血清FFA、ApoE及sST2水平;分析影响AIS患者病情转归的因素;分析ApoE、sST2及FFA表达单独及联合检测对AIS患者转归的预测价值。结果:转归不良组的高血压和高血脂情况显著增多;血清ApoE、sST2及FFA的表达均明显低于转归不良组(P<0.05)。多因素Logistic分析显示,高血压、高血脂、ApoE、sST2及FFA表达均为病情转归的影响因素(P<0.05)。经ROC曲线分析可得,ApoE、sST2及FFA预测AIS患者转归的AUC值分别为0.768、0.740、0.801;联合检测的AUC值为0.874。结论:高血压、高血脂、ApoE、sST2及FFA表达均为病情转归的影响因素,且ApoE、sST2及FFA三项指标联合预测AIS患者的病情转归更有效。Objective:To investigate the predictive value of serum levels of Apolipoprotein E(ApoE),soluble growth stimulation expressed gene 2(SST2)and Free fatty acid(FFA)in patients with acute ischemic stroke.Methods:a total of 163 patients with Acute ischemic stroke(AIS)admitted to the Department of Neurology from January 2020 to December 2022 were selected,according to the outcome of 90 days after onset,the patients were divided into good outcome group and bad outcome group.The baseline data were collected,and the serum levels of FFA,ApoE and SST2 were measured and compared between the two groups to analyze the prognostic value of ApoE,SST2 and FFA expression alone or in combination in AIS patients.Results:the levels of serum ApoE,SST2 and FFA in the poor outcome group were significantly lower than those in the poor outcome group(P<0.05).Multivariate Logistic analysis showed that hypertension,hyperlipemia,ApoE,SST2 and FFA were the influencing factors(P<0.05).The AUC values of ApoE,SST2 and FFA were 0.768,0.740 and 0.801,respectively,and the AUC values of ApoE,SST2 and FFA were 0.874,respectively.Conclusion:hypertension,hyperlipemia,ApoE,SST2 and FFA are all the factors affecting the prognosis of AIS,and the combination of ApoE,SST2 and FFA is more effective in predicting the prognosis of AIS.

关 键 词：游离脂肪酸 载脂蛋白E 缺血性 脑卒中 病情转归 

分 类 号：R743.3[医药卫生—神经病学与精神病学]