非酒精性脂肪性肝病多组学研究现状  

Advances in the multi-omics research on nonalcoholic fatty liver disease

作　　者：段明秀 陈新利[1] 常伟宇 杨媛[1] 杨仕琦 吴晖[1] DUAN Mingxiu;CHEN Xinli;CHANG Weiyu;YANG Yuan;YANG Shiqi;WU Hui(Centre for Clinical Pharmacy,The First Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院临床药学中心,昆明650000

出　　处：《临床肝胆病杂志》2024年第6期1240-1247,共8页Journal of Clinical Hepatology

基　　金：云南省应用基础研究专项项目(202301AT070152)。

摘　　要：非酒精性脂肪性肝病(NAFLD)在全球范围内患病率高达30%,严重影响人类健康并构成公共卫生负担。由于该病难以诊断和监控,因此,识别潜在的药物靶点和生物标志物具有重要价值,多组学技术在探索NAFLD早期诊断标志物、治疗靶点、疗效和预后评估方面具有广阔的前景。本文对近年来多组学技术在NAFLD中领域的研究进展进行综述,以期为NAFLD的防治提供更为丰富的理论依据和新的策略。The prevalence rate of nonalcoholic fatty liver disease(NAFLD)reaches up to 30%around the world,and the disease has a serious impact on human health and constitutes a public health burden.Due to difficulties in the diagnosis and monitoring of NAFLD,it is important to identify potential drug targets and biomarkers,and multi-omics techniques hold great promise in the search for early diagnostic markers,therapeutic targets,and outcome and prognostic assessment of NAFLD.This article reviews the research advances in multi-omics techniques in the field of NAFLD in recent years,in order to provide a richer theoretical basis and new strategies for the prevention and treatment of NAFLD.

关 键 词：非酒精性脂肪性肝病 基因组学 蛋白质组学 代谢组学 胃肠道微生物组 

分 类 号：R575.5[医药卫生—消化系统]