小窝蛋白1在肝脏疾病中的调控作用  

Regulatory effect of caveolin-1 in liver diseases

作　　者：朱骏毅 李瑞蕊 舒仪雪 孙泉[1] ZHU Junyi;LI Ruirui;SHU Yixue;SUN Quan(School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学基础医学院,北京100069

出　　处：《临床肝胆病杂志》2024年第6期1269-1274,共6页Journal of Clinical Hepatology

基　　金：北京市自然科学基金面上项目(7222009)。

摘　　要：小窝蛋白(CAV)1是质膜上小窝的结构蛋白,是肝脏功能的重要调节因子。CAV1可通过多种分子通路调节肝脏脂质沉积、脂质和葡萄糖代谢、线粒体功能和肝细胞增殖等。因此,CAV1在肝脂肪变性和肝细胞增殖等代谢调节过程中维持肝脏生理方面起着至关重要的作用。此外,CAV1还参与调节不同类型肝损伤、肝炎、肝硬化等疾病的发生发展过程。本文就CAV1在肝脏及相关疾病中的作用及调控肝巨噬细胞的机制进行综述,为靶向CAV1治疗肝脏相关疾病提供理论依据。Caveolin-1(CAV1)is a structural protein of caveolae on the plasma membrane and is an important regulatory factor for liver function.CAV1 regulates hepatic lipid deposition,lipid and glucose metabolism,mitochondrial function,and hepatocyte proliferation through various molecular pathways.Therefore,CAV1 plays a crucial role in maintaining liver physiology during the metabolic regulatory processes such as hepatic steatosis and hepatocyte proliferation.Furthermore,CAV1 is also involved in the development and progression of different types of liver injury,hepatitis,and liver cirrhosis.This article reviews the role of CAV1 in liver-related diseases and its mechanism in the regulation of liver macrophages,so as to provide a theoretical basis for targeting CAV1 in the treatment of liver-related diseases.

关 键 词：小窝蛋白1 化学性与药物性肝损伤 肝纤维化 巨噬细胞 

分 类 号：R575[医药卫生—消化系统]