Bim蛋白在抗肿瘤中的研究进展  

Research progress of Bim protein in antitumor

作　　者：李楠 马吉勇[2] LI Nan;MA Jiyong(The Third Clinical School of Medicine,Nanjing Medical University,Nanjing 211166,Jiangsu Province,China;Department of Respiratory Medicine,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing 210006,Jiangsu Province,China)

机构地区：[1]南京医科大学第三临床医学院,江苏南京211166 [2]南京医科大学附属南京医院呼吸科,江苏南京210006

出　　处：《世界临床药物》2024年第5期537-541,共5页World Clinical Drug

摘　　要：B细胞淋巴瘤-2细胞死亡相互作用调节子(B cell lymphoma-2 interacting mediator of cell death,Bim)是B细胞淋巴瘤(B cell lymphoma,Bcl)-2家族中的重要组成部分,也是Bcl-2凋亡蛋白家族中仅有一个BH3同源结构域的蛋白。Bim通过BH3结构域与Bcl-2中凋亡成员结合或直接活化促凋亡分子,诱导细胞凋亡。Bim蛋白的低表达与多种肿瘤的发生发展、预后及抗肿瘤药物的耐药性等密切相关。调控Bim蛋白表达已成为当前研究热点。该文将对Bim蛋白在抗肿瘤中的研究进展作综述。B-cell lymphoma-2 cell death interaction regulator(Bim)is an important component of the B-cell lymphoma(Bcl)-2 family,and is the only protein in the Bcl-2 apoptosis protein family with a BH3 homologous domain.Bim can induce apoptosis by binding to apoptotic members in Bcl-2 through BH3 domain or directly activating proapoptotic molecules.The low expression of Bim protein is closely related to the development,prognosis and anti-tumor drug resistance of various tumors.Regulation of Bim protein expression has become a research hotspot.This article reviewed the research progress of Bim protein in antitumor.

关 键 词：B细胞淋巴瘤-2细胞死亡相互作用调节子蛋白 细胞凋亡 抗肿瘤 

分 类 号：R73[医药卫生—肿瘤]