内镜黏膜下剥离术后食管狭窄的药物预防研究进展  

Research progress of drug prevention of esophageal stenosis after endoscopic submucosal dissection

作　　者：张天天 叶华[2] 柴旭煜[1] ZHANG Tiantian;YE Hua;CHAI Xuyu(National Advanced Medical Engineering Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203,China;Department of Gastrointestinal Surgery,Ningbo NO.2 Hospital,Ningbo 315010,Zhejiang Province,China)

机构地区：[1]中国医药工业研究总院医药先进制造国家工程研究中心,上海201203 [2]宁波市第二医院胃肠外科,浙江宁波315010

出　　处：《世界临床药物》2024年第5期561-566,共6页World Clinical Drug

摘　　要：内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)是在内镜辅助下完全切除整体黏膜病变的微创手术,常用于早期食管癌(esophageal cancer)及癌前病变。但ESD导致的黏膜缺损极易引起食管狭窄,严重影响患者生活质量。目前已有多种药物被尝试用于ESD术后狭窄的预防,应用最成功的是口服和局部注射糖皮质激素。该文从食管狭窄的原因及机制入手,对ESD术后狭窄的预防药物尤其是糖皮质激素作一综述。Endoscopic submucosal dissection(ESD)is a minimally invasive operation to completely resect the overall mucosal lesions with the assistance of an endoscopy,which is often used for early esophageal cancer and precancerous lesions.However,the mucosal defect caused by ESD is very easy to cause esophageal stenosis,which seriously affects the quality of life of patients.At present,many drugs have been tried for the prevention of ESD postoperative stenosis,and the most successful application is oral and local injection of glucocorticoids.Based on the causes and mechanisms of esophageal stenosis,this article reviewed the preventive drugs especially glucocorticoids for ESD postoperative stenosis.

关 键 词：内镜黏膜下剥离术 食管狭窄 糖皮质激素 

分 类 号：R735.1[医药卫生—肿瘤]