老年宫颈癌患者血清LTBP2表达水平及与细胞凋亡的相关性及临床意义  

Expression of Serum LTBP2 in Elderly Patients with Cervical Cancer and Its Correlation with Apoptosis

作　　者：魏娟 付建红[1] 韩晓霞[1] 党国伟[1] WEI Juan;FU Jianhong;HAN Xiaoxia(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第五附属医院,450000

出　　处：《实用癌症杂志》2024年第6期874-877,共4页The Practical Journal of Cancer

摘　　要：目的探讨血清LTBP2水平在老年宫颈癌患者中的表达及与细胞凋亡水平的相关性及其临床意义。方法选取老年宫颈癌患者72例纳入宫颈癌组,同时期选取老年子宫颈上皮不典型增生(cervical intraepithelial neoplasia,CIN)50例纳入CIN组,再选取体检健康的志愿者50例纳入健康对照组。采用酶联免疫吸附法检测血清LTBP2水平。统计细胞凋亡指数、LTBP2水平,相关性分析老年宫颈癌患者血清LTBP2水平与细胞凋亡水平的关系,血清LTBP2水平与老年宫颈癌患者临床病理特征的关系及手术前后老年宫颈癌患者血清LTBP2水平变化。结果宫颈癌组细胞凋亡指数较CIN组低(P<0.05)。宫颈癌组血清LTBP2水平较健康对照组、GIN组均高(P<0.05)。老年宫颈癌患者血清LTBP2水平与细胞凋亡水平呈负相关(γ=-0.824,P<0.001)。血清LTBP2水平与老年宫颈癌组织临床分期、分化程度、淋巴结转移有关(P<0.05),与年龄、肿瘤直径、肌层浸润深度及脉管癌栓无关(P>0.05)。手术前与手术后老年宫颈癌患者血清LTBP2水平比较,差异有统计学意义(P<0.05),其中术后6月血清LTBP2水平最低。结论血清LTBP2水平在老年宫颈癌患者血清中表达呈现升高趋势,且与细胞凋亡指数呈负相关。血清LTBP2水平与宫颈癌组织临床分期、分化程度、淋巴结转移有关,临床可通过监测血清LTBP2水平评估患者病情进展程度,具有较高临床价值。Objective To investigate the expression of serum LTBP2 in elderly patients with cervical cancer and its correlation with cell apoptosis.Methods 72 cases of elderly cervical cancer patients were included in the cervical cancer group,while 50 cases of elderly cervical intraepithelial neoplasia(CIN)were included in the CIN group during the same period.Then 50 healthy volunteers were selected as healthy control group.Serum LTBP2 levels were detected by enzymed-linked immunosorbent assay.The apoptotic index and LTBP2 level were analyzed.The correlation between serum LTBP2 level and apoptosis level in elderly patients with cervical cancer was analyzed,and the correlation between serum LTBP2 level and clinicopathological features in elderly patients with cervical cancer was analyzed,as well as the changes of serum LTBP2 level in elderly patients with cervical cancer before and after surgery.Results The apoptosis index of the cervical cancer group was lower than that of the GIN group.The level of LTBP2 in the cervical cancer group was higher than that of the healthy control group and GIN group,P<0.05.Serum LTBP2 level was positively negatived with apoptosis level in elderly patients with cervical cancer(γ=-0.824,P<0.001).Serum LTBP2 level was correlated with clinical stage,differentiation degree and lymph node metastasis of cervical cancer tissue in the elderly(P<0.05),but was not correlated with age,tumor diameter,depth of muscle invasion and vascular cancer thrombus(P>0.05).The serum LTBP2 level of elderly cervical cancer patients before and after surgery was compared,P<0.05.The serum LTBP2 level was the lowest 6 months after surgery,3 months after surgery,1 month after surgery,and the comparison between groups was P<0.05.Conclusion Serum LTBP2 expression is on the rise in elderly patients with cervical cancer,and is positively negatived with the apoptosis index,which is related to the clinical stage,differentiation degree and lymph node metastasis of cervical cancer tissue.Clinical monitoring of serum LTBP2 level can

关 键 词：LTBP2 老年 宫颈癌 细胞凋亡 相关性 

分 类 号：R737.33[医药卫生—肿瘤]