Smo和Gli1蛋白在眼睑基底细胞癌组织中的表达及临床意义  

Expression and Clinical Significance of Smo and Gli1 Protein in Eyelid Basal Cell Carcinoma

作　　者：姬翔[1] 李杰 张翔 沈玲[1] JI Xiang;LI Jie;ZHANG Xiang(Jiaozuo People's Hospital,Jiaozuo,454000)

机构地区：[1]河南省焦作市人民医院,454000 [2]河南省立眼科医院,450003 [3]焦作市中医院,454000

出　　处：《实用癌症杂志》2024年第6期904-907,928,共5页The Practical Journal of Cancer

摘　　要：目的探讨Smo和Gli1蛋白在眼睑基底细胞癌(EBCC)组织中的表达及临床意义。方法选取焦作市人民医院眼科收治的眼睑基底细胞癌患者40例为研究对象,采用免疫组织化学方法检测EBCC患者癌组织及癌旁组织细胞内Smo和Gli1蛋白的表达。设计资料调查表,详细统计所选患者的基本资料,分析不同病理特征EBCC患者组织中Smo和Gli1蛋白的表达情况,并分析组织中Smo和Gli1蛋白表达不同的眼睑基底细胞癌患者预后情况。结果EBCC组织中Smo蛋白阳性表达率显著高于癌周正常黏膜组织(P<0.05);EBCC组织中Gli1蛋白阳性表达率显著高于癌周正常黏膜组织(P<0.05)。不同的性别、年龄、BMI、发病部位患者的癌组织中Smo与Gli1蛋白表达比较,差异无统计学意义(P>0.05);不同肿瘤分化程度患者癌组织中Smo与Gli1蛋白表达比较,差异有统计学意义(P<0.05)。经Log-rank检验,Smo和Gli1蛋白阴性表达患者1年内复发率均明显低于阳性患者(P<0.05)。经Kendall’s tau-b相关分析结果发现,组织中Smo蛋白表达与Gli1蛋白表达呈正相关(γ=0.350,P=0.010)。结论Smo和Gli1蛋白在EBCC组织中的阳性表达率更高,可以作为EBCC早期诊断的标志物。Smo和Gli1蛋白的表达水平与分化程度有关,且与EBCC预后有密切关系,可以在临床上为眼睑基底细胞癌的发展与预后评估提供参考。Objective To investigate the expression and clinical significance of Smo and Gli1 protein in eyelid basal cell carcinoma(EBCC).Methods 40 patients with eyelid basal cell carcinoma were selected as the study subjects.Immunohistochemical methods were used to detect the expression of Smo and Gli1 protein in the cancer tissues and adjacent tissues of EBCC patients.The data questionnaire was designed to make detailed statistics on the basic data of the selected patients,analyze the expression of Smo and Gli1 protein in the tissues of EBCC patients with different pathological characteristics,and analyze the prognosis of patients with eyelid basal cell carcinoma with different expression of Smo and Gli1 protein in tissues was analyzed.Results The positive expression rate of Smo protein in the tissues of EBCC patients was significantly higher than that in the normal mucosa around the cancer(P<0.05);The positive expression rate of Gli1 protein in the tissues of EBCC patients was significantly higher than that in the normal mucosa around the cancer(P<0.05);There was no statistically significant difference in the expression of Smo and Gli1 protein in the tissues of patients with different sex,age,BMI and disease site(P>0.05);The expression of Smo and Gli1 protein in the tissues of patients with different tumor differentiation levels was significantly different(P<0.05);Log-rank test showed that the recurrence rate of Smo and Gli1 protein negative patients within 1 year was significantly lower than that of positive patients(P<0.05);Kendall's tau-b correlation analysis showed that the expression of Smo protein in tissues was positively correlated with the expression of Gli1 protein(γ=0.350,P=0.010).Conclusion The positive expression rate of Smo and Gli1 protein in EBCC tissue is higher,which can be used as a marker for early diagnosis of EBCC;The expression level of Smo and Gli1 protein is related to the degree of differentiation,and is closely related to the prognosis of EBCC,which can provide a reference for the development

关 键 词：眼睑基底细胞癌 Smo蛋白 GLI1蛋白 免疫组织化学 

分 类 号：R739.71[医药卫生—肿瘤]