胰腺癌中Fas、CCR4表达及与临床病理参数及预后的关系  

Expressions of Fas and CCR4 in Pancreatic Cancer and Relationship with Clinicopathological Parameters and Prognosis

作　　者：韩万斌 鲁旭 HAN Wanbin;LU Xu(West China Guang'an Hospital,Sichuan University,Guang'an,638500)

机构地区：[1]四川大学华西广安医院,638500

出　　处：《实用癌症杂志》2024年第6期912-916,共5页The Practical Journal of Cancer

摘　　要：目的分析胰腺癌中Fas、趋化因子受体4(CCR4)的表达及与临床病理参数及预后的关系。方法收集手术治疗的118例胰腺癌患者癌组织标本及距离癌组织边缘4 cm以上的癌旁正常组织标本,采用免疫组织化学染色法检测118例癌组织及癌旁正常组织中Fas、CCR4表达情况,并分析Fas、CCR4表达与胰腺癌患者临床病理参数及预后的关系。结果胰腺癌癌组织中Fas阳性表达率显著低于癌旁正常组织(P<0.05),CCR4阳性表达率显著高于癌旁正常组织(P<0.05)。Fas表达与胰腺癌分化程度(P=0.005)、淋巴结转移(P=0.011)有关,与性别、年龄、肿瘤部位、肿瘤大小、TNM分期、血管侵犯无关(P均>0.05);CCR4表达与TNM分期(P=0.006)、淋巴结转移(P=0.027)有关,与性别、年龄、肿瘤部位、肿瘤大小、分化程度、血管侵犯无关(P均>0.05)。Fas阳性表达组总生存率显著高于Fas阴性表达组(P<0.05),CCR4阳性表达组总生存率显著低于CCR4阴性表达组(P<0.05)。淋巴结转移(P=0.013)、Fas表达(P=0.018)、CCR4表达(P=0.022)是影响胰腺癌患者预后的独立危险因素。结论Fas低表达及CCR4高表达可能与胰腺癌的发生发展有关,可用作评估胰腺癌预后的重要指标。Objective To analyze the expressions of Fas and chemokine receptor 4(CCR4)in pancreatic cancer and the relationship with clinicopathological parameters and prognosis.Methods The cancer tissue specimens and the adjacent normal tissue specimens more than 4 cm away from the edge of the cancer tissue were collected from 118 patients with pancreatic cancer who received surgical treatment.Immunohistochemical staining was used to detect the expressions of Fas and CCR4 in cancer tissues and adjacent normal tissues of 118 cases,and the relationship of expressions of Fas and CCR4 with clinicopathological parameters and prognosis in patients with pancreatic cancer was analyzed.Results The positive expression rate of Fas in pancreatic cancer tissues was significantly lower than that in adjacent normal tissues(P<0.05),while the positive expression rate of CCR4 was significantly higher than that in adjacent normal tissues(P<0.05).Fas expression was related to differentiation degree of pancreatic cancer(P=0.005)and lymph node metastasis(P=0.011),but was not associated with gender,age,tumor location,tumor size,TNM staging and vascular invasion(all P>0.05).CCR4 expression was associated with TNM staging(P=0.006)and lymph node metastasis(P=0.027),but was not related to gender,age,tumor location,tumor size,degree of differentiation and vascular invasion(all P>0.05).The overall survival rate of Fas positive expression group was significantly higher than that of Fas negative expression group(P<0.05),and the overall survival rate of CCR4 positive expression group was significantly lower than that of CCR4 negative expression group(P<0.05).Lymph node metastasis(P=0.013),Fas expression(P=0.018),and CCR4 expression(P=0.022)were independent risk factors affecting the prognosis in patients with pancreatic cancer.Conclusion The low expression of Fas and the high expression of CCR4 may be related to the occurrence and development of pancreatic cancer,and can be used as important indicators to evaluate the prognosis of pancreatic cancer.

关 键 词：胰腺癌 FAS 趋化因子受体4 病理参数 预后 

分 类 号：R735.9[医药卫生—肿瘤]