CTLA-4、STAT3在宫颈鳞状上皮内病变及宫颈癌组织中的表达及其意义  

The Expression and Significance of CTLA-4 and STAT3 in Cervical Squamous Intraepithelial Lesions and Cervical Cancer Tissues

作　　者：吕晓佩 LV Xiaopei(Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第二附属医院,450000

出　　处：《实用癌症杂志》2024年第6期925-928,共4页The Practical Journal of Cancer

摘　　要：目的分析细胞毒性T淋巴细胞抗原4(CTLA-4)、信号传导及转录激活因子3(STAT3)在宫颈鳞状上皮内病变(SIL)与宫颈癌(CC)组织中的表达及其意义。方法将42例慢性宫颈炎患者、61例SIL患者与65例CC患者分别纳入对照组、SIL组、CC组,以专用人乳头瘤病毒(HPV)标本采样刷采集所有患者的宫颈脱落细胞,采用免疫组化法检测所有患者的CTLA-4、STAT3表达;同时,收集所有患者的一般资料,分析CTLA-4、STAT3阳性表达与患者临床病理特征的关系。结果CC组CTLA-4、STAT3阳性表达率高于SIL组与对照组,且SIL组CTLA-4、STAT3阳性表达率高于对照组,差异有统计学意义(P<0.05);CTLA-4、STAT3表达与SIL患者的病理分级有关,与CC患者的国际妇产科联盟(FIGO)分期有关(P<0.05);CTLA-4、STAT3表达与SIL患者年龄无关,CTLA-4、STAT3表达与CC患者年龄、淋巴结转移、病理类型、宫颈肌壁浸润深度无关(P>0.05)。结论CTLA-4、STAT3在SIL、CC患者的机体内呈异常表达,随着疾病等级与分期的增加,两者阳性表达率不断提高。Objective To analyze the expression and significance of cytotoxic T lymphocyte antigen-4(CTLA-4)and signal transduction and transcription activating factor 3(STAT3)in cervical squamous intraepithelial lesions(SIL)and cervical cancer(CC)tissues.Methods 42 patients with chronic cervicitis,61 patients with SIL,and 65 patients with CC were included in the control group,SIL group,and CC group,respectively.Cervical exfoliated cells were collected from all patients using a dedicated human papillomavirus(HPV)specimen sampling brush,and the expression of CTLA-4 and STAT3 in all patients was detected by immunohistochemistry;At the same time,collect general information from all patients and analyze the relationship between the positive expression of CTLA-4 and STAT3 and the clinical and pathological characteristics of patients.Results The positive expression rates of CTLA-4 and STAT3 in the CC group were higher than those in the SIL group and the control group,and the positive expression rates of CTLA-4 and STAT3 in the SIL group were higher than those in the control group,with statistical significance(P<0.05);The expression of CTLA-4 and STAT3 is related to the pathological grading of SIL patients and the International Federation of Obstetrics and Gynecology(FIGO)staging of CC patients(P<0.05);The expression of CTLA-4 and STAT3 is not related to the age of SIL patients,while CTLA-4 and STAT3 are not related to the age,lymph node metastasis,pathological type,and depth of cervical muscle wall infiltration in CC patients(P>0.05).Conclusion CTLA-4 and STAT3 are abnormally expressed in the body of SIL and CC patients,and their positive expression rates continue to increase with the increase of disease grade and stage.

关 键 词：宫颈癌 宫颈鳞状上皮内病变 细胞毒性T淋巴细胞抗原4 信号传导及转录激活因子3 

分 类 号：R737.33[医药卫生—肿瘤]