阴性淋巴结数对浸润性乳腺癌预后的评估价值  

Prognostic Value of Negative Lymph Nodes in Invasive Breast Cancer

作　　者：郭宏燕 崔抗[1] 杨红梅 GUO Hongyan;CUI Kang;YANG Hongmei(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第6期1025-1027,1032,共4页The Practical Journal of Cancer

摘　　要：目的分析阴性淋巴结数对浸润性乳腺癌(IBC)患者预后的评估价值。方法回顾性分析84例IBC患者的病历有关资料,统计其阴性淋巴结检出数目,分析淋巴结数目与IBC患者临床病理特征以及预后的关系。结果84例IBC患者,共检出648枚阴性淋巴结,人均检出7.7枚;将人均检出的7.7枚阴性淋巴结取整数后,以阴性淋巴结检出数目8枚作为界值,把所有患者划分为2组,其中阴性淋巴结≥8枚组共38例,阴性淋巴结<8枚组共46例。2组的年龄、BMI、疾病类型相比,差异无统计学意义(P>0.05);而阴性淋巴结≥8枚组中TNM为Ⅰ~Ⅱ期、辅助化疗患者占比分别为78.95%(30/38)、68.42%(26/38),高于阴性淋巴结<8枚组的34.78%(16/46)、28.26%(13/46),差异有统计学意义(P<0.05)。阴性淋巴结≥8枚组的1年生存率为92.11%(35/38),高于阴性淋巴结<8枚组的73.91%(34/46),差异有统计学意义(P<0.05)。结论阴性淋巴结检出数与IBC患者的预后密切相关,阴性淋巴结检出数少,则患者预后差,临床需予以高度关注。Objective To analyze the prognostic value of the number of negative lymph nodes in patients with invasive breast cancer(IBC).Methods A retrospective analysis was conducted on the medical records of 84 patients with IBC,and the number of negative lymph nodes detected was counted.The relationship between the number of lymph nodes and the clinical pathological characteristics and prognosis of IBC patients was analyzed.Results A total of 648 negative lymph nodes were detected in 84 IBC patients,with 7.7 nodes detected per person;After rounding off the 7.7 negative lymph nodes detected per capita,all patients were divided into 2 groups with a cut-off value of 8 negative lymph nodes.Among them,there were 38 cases in the group with negative lymph nodes≥8 and 46 cases in the group with negative lymph nodes<8.There was no statistically significant difference in age,BMI,and disease type between the 2 groups(P>0.05);In the group with negative lymph nodes≥8,the proportion of TNM patients in stages I to II and adjuvant chemotherapy patients was 78.95%(30/38)and 68.42%(26/38),respectively,which was higher than the 34.78%(16/46)and 28.26%(13/46)in the group with negative lymph nodes<8,and the difference was statistically significant(P<0.05);The one-year survival rate of the group with negative lymph nodes≥8 was 92.11%(35/38),which was higher than the 73.91%(34/46)of the group with negative lymph nodes<8,and the difference was statistically significant(P<0.05).Conclusion The number of negative lymph nodes is closely related to the prognosis of patients with IBC.If the number of negative lymph nodes is small,the prognosis of patients with IBC is poor.

关 键 词：浸润性乳腺癌 阴性淋巴结数 预后 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]