轻度认知障碍患者的回溯式时距估计  

Retrospective Time Estimation of Patients with Mild Cognitive Impairment

作　　者：王亚琪 付鹏蕊 马文[1,2] 王萍[3] Wang Yaq;Fu Pengrui;Ma Wen;Wang Ping(SchoolofForeign Languages and Literature,Shandong University,Jinan,250100;Center for Language Science,Shandong University,Jinan250100;The Second Hospital of Shandong University,Jinan250033;Cheeloo College of Medicine,Shandong University,Jinan 250012)

机构地区：[1]山东大学外国语学院,济南250100 [2]山东大学语言科学实验中心,济南250100 [3]山东大学第二医院,济南250033 [4]山东大学齐鲁医学院,济南250012

出　　处：《心理科学》2024年第3期522-529,共8页Journal of Psychological Science

基　　金：山东省社科规划研究青年项目(20DYYJ04)的资助。

摘　　要：阿尔茨海默病会导致时间知觉障碍,然而尚处于该疾病潜伏期的轻度认知障碍患者是否也存在时间知觉的损伤仍存争议。本研究聚焦轻度认知障碍对回溯式时间知觉的影响,通过回溯式时距估计任务探讨了轻度认知障碍患者和健康老人对15至40分钟的目标时距的回溯式估计。研究发现,相比于控制组,轻度认知障碍患者存在显著低估时距的倾向且时距估计的偏差更大。研究论证了轻度认知障碍对时间感知的影响,对阿尔茨海默病的早期诊断具有重要价值。Mild Cognitive Impairment(MCI)denotes the clinical stage between healthy aging and Alzheimer's disease(AD).There is emerging evidence indicating that patients with AD suffer from time distortion,but it remains controversial whether MCI patients also show compromised ability in time perception.The current study aims to investigate the time perception ability of MCI patients and to examine whether time distortion can be observed at the pre-clinical stage of Alzheimer's disease.Using the retrospective time estimation task,the current study tested 34 MCI patients and 34 healthy controls,who are matched in age,education,and gender.Before the experiment,participants were tested with Mini-Mental State Examination(MMSE)by a clinician,and the diagnoses and group allocation remained unknown to the participants until the end of the experiment.After diagnoses,participants were exposed to the target interval by engaging in a naming task.In this task,participants were first given an eye-sight check and correction.And then,following the naming task instruction and practice,they were informed to verbally report the names of 36 objects and 36 scenes in the pictures on a computer screen.There was no time limit for their responses,and their responses were recorded at the same time.While accomplishing the naming task,all participants were surprisingly asked to estimate the clock time between the onset of eye-sight check and the end of naming task.The target intervals ranged between 15 to 40 minutes,and participants were unaware of the timing task when they were exposed to the target intervals.In data analysis,interval ratio(estimated clock time/original clock time)and interval distortion ratio(lestimated clock time-original clock timel/original clock time)were calculated respectively to indicate the overestimation/underestimation tendency and the degree of estimation distortion.With independent samples t-tests,it was found that though MCI patients did not differ significantly from the control groups in the naming task,they underesti

关 键 词：轻度认知障碍 时间知觉障碍 回溯式时距估计任务 长时距知觉 

分 类 号：R749.1[医药卫生—神经病学与精神病学]