五环三萜类天然产物研究进展  

Research advances of pentacyclic triterpenoid natural products

作　　者：丁雯昕 杜柏霖 李娇 庄春林 DING Wen-xin;DU Bai-lin;LI Jiao;ZHUANG Chun-lin(School of Pharmacy,Second Military Medical University,Shanghai 200433,China)

机构地区：[1]中国人民解放军海军军医大学药学院,上海200433

出　　处：《药学学报》2024年第5期1163-1175,共13页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金优秀青年基金资助项目(82022065);上海市曙光学者计划资助项目(21SG38)。

摘　　要：五环三萜类化合物是自然界广泛存在的一类含有六个异戊二烯五环结构的重要天然产物,具有广泛的药理活性,包括抗菌、抗炎、抗病毒、抗肿瘤、免疫调节等。基于五环三萜类天然产物的结构修饰及新药开发一直是国内外研究的热点。本文综述了近年来不同种类五环三萜天然产物的结构修饰、药理作用以及临床研究的相关进展。Pentacyclic triterpenoids are a class of widespread natural compounds containing six isoprene structures with a wide range of pharmacological activities,including antibacterial,anti-inflammatory,antiviral,antitumor,immune regulation,etc.The structural modifications of pentacyclic triterpenoid natural products and the drug development have always been a hot research topic.This article reviews the recent progresses in the structural modifications,pharmacological effects,and clinical studies of different kinds of pentacyclic triterpenoid natural products.

关 键 词：五环三萜 结构修饰 生物活性 临床研究 研究进展 

分 类 号：R914[医药卫生—药物化学]