金属有机框架纳米药物载体胞吞途径的研究进展  

Research progress on the endocytosis pathway of nanoscale metalorganic frameworks drug carriers

作　　者：王宇轩 谢雯佳 高会乐[2] 裴锡波 WANG Yu-xuan;XIE Wen-jia;GAO Hui-le;PEI Xi-bo(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,West China School of Pharmacy,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院修复科,口腔疾病防治全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川成都610041 [2]四川大学华西药学院,靶向药物及释药系统教育部重点实验室,四川成都610041

出　　处：《药学学报》2024年第5期1196-1209,共14页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上项目(82271016);四川省中央引导地方科技发展专项项目(2023ZYD0109);华西口腔交叉学科创新项目(RD-03-202310)。

摘　　要：金属有机框架(metal-organic frameworks,MOFs)是一类以金属离子为结点,有机配体为连接桥,通过配位键形成的多维孔道网格结构的晶体材料,因其具有良好的理化性能,被广泛地应用于杀菌、载药、成像、检测等生物医学领域。纳米金属有机框架(nanoscale metal-organic frameworks,nMOFs)作为常用药物载体,经过胞吞入胞能够获得更安全的靶向性及更优异的疗效。本文从粒径、形态、表面改性三大理化性质对nMOFs药物载体胞吞的影响因素进行综述,并以疾病类型为分类依据总结nMOFs胞吞途径最新研究进展,反思相关研究方法存在的不足。最后对未来的研究手段和研究目标进行展望,以期为nMOFs药物载体的合成与开发提供一定思路和借鉴意义。Metal-organic frameworks(MOFs) are crystalline materials with a multidimensional porous network structure,formed through coordination bonds with metal ions as nodes and organic ligands as connecting bridges.Due to their excellent physicochemical properties,MOFs have extensive applications in the field of biomedicine,ranging from antibacterials,drug carriers,imaging to sensors.Nanoscale metal-organic frameworks(nMOFs),commonly utilized drug carriers,can gain enhanced safety,targeted delivery,and superior therapeutic effect through endocytosis.In this review,we comprehensively summarize the factors influencing the endocytosis of nMOFs,focusing on three key physicochemical properties,particle size,morphology and surface modification.Based on different illness models,the review succinctly summarizes the latest advancements in understanding the endocytosis pathways of nMOFs while critically reflecting on the inherent limitations of current research methods.Lastly,the review offers valuable insights into future research methodologies and objectives,aiming to lay the groundwork and provide meaningful guidance for the synthesis and development of nMOFs as promising versatile drug carriers.

关 键 词：金属有机框架 药物载体 胞吞 纳米材料 药物治疗 

分 类 号：R943[医药卫生—药剂学]