SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice  

在线阅读下载全文

作  者:Yifan Wu Freedom M.Green Stephen A.Shaw Lauren J.Bonilla Shannon E.Ronca Maria Elena Bottazzi Farrah Kheradmand Jill E.Weatherhead 

机构地区:[1]Department of Pathology&Immunology,One Baylor Plaza,Houston,TX 77030,USA [2]Department of Pediatrics,One Baylor Plaza,Houston,TX 77030,USA [3]Department of Medicine,One Baylor Plaza,Houston,TX 77030,USA [4]National School of Tropical Medicine,One Baylor Plaza,Houston,TX 77030,USA [5]Molecular Virology&Microbiology,One Baylor Plaza,Houston,TX77030,USA [6]Biologyof Inflammation Center,Baylor College of Medicine,One BaylorPlaza,Houston,TX77030,USA [7]Michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases,Houston,TX 77030,USA

出  处:《Genes & Diseases》2024年第4期9-12,共4页基因与疾病(英文)

基  金:supported by immunophenotyping assessment in a COVID-19 cohort(IMPACC)and has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases,National Institutes of Health,under Contract numbers NO1-Al-25496 and NO1-Al-25482;Nancy Chang,Ph.D.Award for Research Excellence,Baylor College of Medicine.

摘  要:Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)pandemic.In viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关 键 词:PATHOLOGY ACUTE RESPIRATORY 

分 类 号:R373[医药卫生—病原生物学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象