Transcriptomic analysis reveals that NIBAN1 overexpression is associated with BRAF^(V600E)mutation and increases the aggressiveness of thyroid cancer  

作　　者：Paula Diana Thaise Nayane Ribeiro Carneiro Janete Maria Cerutti Reginaldo Massanobu Kuroshu Gianna Maria Griz Carvalheira 

机构地区：[1]Division of Genetics,Department of Morphology and Genetics,Escola Paulista de Medicina,Universidade Federal de Sao Paulo,Sao Paulo,Rua Botucatu,740,Edificio Leitaoda Cunha,1Andar,Sao Paulo,SP04023900,Brazil [2]Genetic Bases of Thyroid Tumors Laboratory,Division of Genetics,Department of Morphology and Genetics,Escola Paulista de Medicina,Universidade Federal de Sao Paulo,Pedro de Toledo 669,11Andar,Sao Paulo,SP 04039-032,Brazil [3]Institute of Science and Technology,Universidade Federal de Sao Paulo,Av Cesare Mansueto Giulio Lattes,1201,Eugenio deMello,SaoJose dos Campos,SP12247-014,Brazil

出　　处：《Genes & Diseases》2024年第4期16-19,共4页基因与疾病（英文）

基　　金：supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)(N°.88882.430337/2019-01);Fundacao de Amparo a Pesquisa do EstadodeSaoPaulo(FAPESP)(N°.2014/06570-6and2015/04164-3);Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq)(N°.470441/2013-5).

摘　　要：NIBAN1 overexpression has been reported in a widerange of thyroid carcinoma subtypes,and in other cancers,while it is not expressed in thyroid benign lesions and normal thy-roid.1-3 However,the mechanism associated with its expression and prognostic value remains unclear.In this study,six independent cohorts were enrolled,in which NIBAN1 expression was evaluated.A total of 583patients with thyroid tumors,326 patients with skin cancers,293 patients with colorectal carcinoma,and 189 patients with lung carcinoma were analyzed.

关 键 词：BRAF LESIONS BAN 

分 类 号：R736.1[医药卫生—肿瘤]