Exploring the molecular landscape of NNK-induced transformation:A comprehensive genome-wide CRISPR/Cas9 screening  

作　　者：Trang Dinh Mira Rahm Zhenghe Wang Christopher McFarland Athar Khalil 

机构地区：[1]Department of Genetics and Genome Sciences,Case WesternReserve University,Cleveland,OH44106,USA

出　　处：《Genes & Diseases》2024年第4期42-44,共3页基因与疾病（英文）

基　　金：supported by grants from the National Institutes of Health(No.R01CA271540,R00CA226506 to CM,No.R01CA196643,R01CA264320,R01CA260629,P50CA150964,and P30 CA043703 to ZW).

摘　　要：Lung cancer is the leading cause of cancer-related deaths worldwide,with an estimated 1.8 million deaths in 2020 alone.1 While several risk factors are associated with lung cancer,smoking remains the most significant environmental cause of the disease.1 One of the most potent carcinogens in tobacco smoke is 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK),which is produced from nicotine through a series of metabolic reactions.

关 键 词：CRISPR/Cas9 NNK LUNG 

分 类 号：R730[医药卫生—肿瘤]