Characterization of SH3GLB1 in the Checkfor auditory system and its potential role in updates mitophagy  

作　　者：Xue Gao Weiqian Wang Jincao Xu Shasha Huang Kun Yang Jinyuan Yang Yijin Chen Guojian Wang Mingyu Han Zhendong Wang Dongyang Kang Yongyi Yuan Pu Dai 

机构地区：[1]College of Otolaryngology Head and Neck Surgery,Chinese PLA General Hospital,Chinese PLA Medical School,Beijing 100853,China [2]National Clinical Research Center for Otolaryngologic Diseases,State Key Lab of Hearing Science,Ministry of Education,Beijing 100853,China [3]Beijing Key Lab of Hearing Impairment Prevention and Treatment,Chinese PLA Medical School,Beijing 100853,China [4]Department of Otolaryngology,PLA Rocket Force Characteristic Medical Center,Beijing 100088,China

出　　处：《Genes & Diseases》2024年第4期61-64,共4页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.82171158,82271177,82271185,82171155);the National Key Research and Development,Project of China(No.2020YFC2008500).

摘　　要：Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关 键 词：AUDITORY MAINTAIN POTENTIAL 

分 类 号：R76[医药卫生—耳鼻咽喉科]