Twenty years of Gendicine?rAd-p53 cancer gene therapy:The first-in-class human cancer gene therapy in the era of personalized oncology  

作　　者：Li Qi Guiqing Li Peipei Li Hongwei Wang Xiaolong Fang Tongchuan He Jingjing Li 

机构地区：[1]Affiliated Hospital of Weifang Medical University,School of Clinical Medicine,Weifang Medical University,Weifang,Shandong 262700,China [2]Jinming Yu Academician Workstation of Oncology,Affiliated Hospital of Weifang Medical University,Weifang,Shandong 262700,China [3]Decording Therapeutics Corp,Shangha 200000,China [4]Yangkun Biogroup Co.,Ltd,Nanjing,Jiangsu 210002,China [5]The University of Chicago,Chicago,IL 60290,USA

出　　处：《Genes & Diseases》2024年第4期234-245,共12页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82104289);the Yuandu Scholar Grant of Weifang City(Shandong,China)to JJL;the Shandong Provincial Health Commission of China(No.M2022053)。

摘　　要：Genetic mutations in TP53 contribute to human malignancies through various means.To date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other approaches.This review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of cancer.Recombinant human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene therapy.We herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical trials.Notably,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy alone.Finally,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.

关 键 词：Gendicine Gene therapy p53 mutation Recombinant p53 adenovirus TP53 

分 类 号：R730.5[医药卫生—肿瘤]