肝细胞癌酸性微环境下免疫细胞的作用和机制的研究进展  

Research advances in the role and mechanisms of immune cells in the acidic microenvironment of hepatocellular carcinoma

作　　者：侯应健 王博石 柳又祎 金成 Hou Yingjian;Wang Boshi;Liu Youyi;Jin Cheng(Department of Hepatobiliary Surgery,Affiliated Hospital of Jiangnan University,Wuxi 214122,China;Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学附属医院肝胆外科,无锡214122 [2]江南大学无锡医学院,无锡214122

出　　处：《中华肝胆外科杂志》2024年第5期386-390,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：江苏省第六期333高层次人才项目(苏人才办2022(2)号);无锡市"太湖之光"科技攻关项目(Y20212018);江苏省卫健委医学科研面上项目(H2023045);无锡市第二届"双百"中青年医疗卫生拔尖人才项目(BJ2023050)。

摘　　要：原发性肝癌形成和进展过程中,逐渐酸化的肿瘤微环境发挥着关键作用。免疫细胞在酸性微环境调控下,分化与功能向免疫抑制发生转变,进一步导致了肝癌免疫逃逸。本文就肝细胞癌肿瘤酸性微环境的形成、酸性微环境下各类免疫细胞的变化及其对肝细胞癌发生发展的作用和其机制进行综述,旨在为肝细胞癌免疫治疗研究提供新思路。The gradually acidified tumor microenvironment plays a key role in the formation and advance of hepatocellular carcinoma.Under the regulation of acidic microenvironment,the differentiation and function of immune cells change to immunosuppression,which further leads to the occurrence of immune escape of hepatocellular carcinoma.In this paper,the formation of acidic microenvironment of hepatocellular carcinoma,the changes of various immune cells in acidic microenvironment and their effects on the occurrence and development of hepatocellular carcinoma,as well as their further mechanisms are reviewed in order to provide new ideas for the study of immunotherapy of hepatocellular carcinoma.

关 键 词：癌 肝细胞 肿瘤微环境 肿瘤逃逸 免疫疗法 免疫细胞 

分 类 号：R735.7[医药卫生—肿瘤]