老年胃癌患者衰弱与人体成分的相关性  

Correlation between frailty and body composition in elderly patients with gastric cancer

作　　者：郭鑫 孟君 郑世良[1,2] 董秀红 GUO Xin;MENG Jun;ZHENG Shiliang;DONG Xiuhong(Department of General Practice,Affiliated Hospital of Weifang Medical University,Weifang 261035,Shandong,China;School of Clinical Medicine,Weifang Medical University,Weifang 261053,Shandong,China;Department of Pulmonary and Critical Care Medicine Department,Yantai Yuhuangding Hospital,Yantai 264000,Shandong,China;Department of Gastroenterology,Affiliated Hospital of Weifang Medical University,Weifang 261035,Shandong,China)

机构地区：[1]潍坊医学院附属医院全科医学科,山东潍坊261035 [2]潍坊医学院临床医学院,山东潍坊261053 [3]烟台毓璜顶医院呼吸与危重症医学科,山东烟台264000 [4]潍坊医学院附属医院消化内科,山东潍坊261035

出　　处：《山东大学学报（医学版）》2024年第4期40-47,共8页Journal of Shandong University:Health Sciences

摘　　要：目的探讨老年胃癌患者衰弱与人体成分的相关性,以评估人体成分对老年癌患者发生衰弱的预测价值。方法选取2021年9月~2023年8月期间在潍坊医学院附属医院经过病理明确诊断的老年胃癌患者96例为研究对象。根据Fried衰弱表型量表(frailty phenotype,FP)将其分为衰弱组和非衰弱组。收集两组患者包括年龄、性别、吸烟、饮酒、肿瘤部位和肿瘤分期等一般临床资料。测量患者的身高、体质量,应用人体成分分析仪对患者人体成分进行检查,包括体质量指数(body mass index,BMI)、体脂肪含量、体脂百分比资料,再根据人体成分中的去脂质量、肌肉质量、上肢肌肉质量、下肢肌肉质量分别计算去脂质量指数(fat free mass index,FFMI)、肌肉质量指数(muscle mass index,MMI)、上肢肌肉质量指数(upper limb muscle mass index,ULMMI)、下肢肌肉质量指数(lower limb muscle mass index,LLMMI)。应用单因素Logistic回归分析,对其与老年癌患者衰弱之间的关联性进行分析;并进行多因素Logistic回归分析,了解其是否为老年胃癌患者衰弱的独立影响因素,并绘制ROC曲线,评估其对老年胃癌患者发生衰弱的预测价值。结果(1)96例老年胃癌患者发生衰弱38例,发生率为39.58%。(2)衰弱组胃癌患者年龄、肿瘤的临床分期均高于非衰弱组(均P<0.05);(3)衰弱组患者体脂肪含量和体脂百分比高于非衰弱组,FFMI、MMI、LLMMI明显低于非衰弱组(均P<0.05)。(4)一般资料中年龄、肿瘤的分期Ⅲ期与Ⅳ期相对于分期Ⅰ期与老年胃癌患者发生衰弱存在着关联;人体成分中FFMI、MMI、LLMMI与老年胃癌患者衰弱呈负相关,体脂肪含量、体脂百分比与老年胃癌患者衰弱呈正相关。(5)校正年龄、肿瘤的临床分期后FFMI、MMI、LLMMI、体脂肪含量、体脂百分比是老年胃癌患者发生衰弱的独立影响因素。(6)ROC曲线结果显示,FFMI、MMI、LLMMI、体脂肪含量、体脂百分比Objective To investigate the correlation between frailty and body composition among elderly patients with gastric cancer,so as to evaluate the efficacy of body composition metrics in forecasting frailty among this demographic.Methods Ninety-six elderly patients with gastric cancer underwent pathological diagnosis at the Affiliated Hospital of Weifang Medical University between September 2021 and August 2023.Utilizing the Fried frailty phenotype(FP),these patients were categorized into either the frailty group or the non-frailty group.Demographic data including age,sex,smoking history,alcohol consumption history,cancer location,cancer stage,body mass index(BMI),body fat content,and body fat percentage were collected for both groups of patients.The fat-free mass index(FFMI),muscle mass index(MMI),upper limb muscle mass index(ULMMI),and lower limb muscle mass index(LLMMI)were computed using the collected data.Univariate Logistic regression analysis was conducted to examine the relationship between these indices and frailty among elderly cancer patients.Subsequently,multivariate Logistic regression analysis was employed to determine if these indices served as independent factors influencing frailty in elderly cancer patients.Additionally,a ROC curve was constructed to assess the predictive capability of these indices for frailty in elderly patients with gastric cancer.Results(1)A total of 96 elderly patients with gastric cancer were included.The incidence of frailty in elderly patients with gastric cancer was 39.58%.(2)The age and clinical stage of gastric cancer in the frailty group were higher than those of the non-fraity group(all P<0.05).(3)Body fat content and body fat percentage in the frailty group were higher than those in the non-frailty group,and FFMI,MMI,and LLMMI were significantly lower than those in the non-frailty group(all P<0.05).(4)Comparison of general data between the two groups revealed that age and clinical stages 3 and 4 of the tumor were associated with the occurrence of frailty in elderly pat

关 键 词：老年 胃癌 衰弱 人体成分 危险因素 

分 类 号：R573[医药卫生—消化系统]