Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet-rich plasma(PRP)  

作　　者：Qian Zhang Yanan Wang Cheng Ran Yingmei Zhou Zigang Zhao Tianhua Xu Hongwei Hou Yuan Lu 

机构地区：[1]Beijing Life Science Academy,Beijing,China [2]Department of Pathology,Affiliated Hospital of Hebei University,Baoding,China [3]Department of Otolaryngology,Affiliated Hospital of Hebei University,Baoding,China [4]Department of Dermatology,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,China [5]Department of Dermatology,Hainan Hospital of PLA General Hospital,Sanya,China [6]Department of Chemical Engineering,Tsinghua University,Beijing,China

出　　处：《Animal Models and Experimental Medicine》2024年第2期106-113,共8页动物模型与实验医学（英文）

基　　金：supported by the Guangdong Enterprise Joint Fund(No.2022A1515220137);The Shenzhen Science and Technology Innovation Committee(No.JCYJ20220530141615035);the Internal project of Huazhong University of Science and Technology Union Shenzhen Hospital(Nos.YN2021042 and YN2021045)。

摘　　要：Background:Androgenic alopecia(AGA)is the most common type of hair loss in men,and there are many studies on the treatment of hair loss by platelet-rich plasma(PRP).The human scalp contains a huge microbiome,but its role in the process of hair loss remains unclear,and the relationship between PRP and the microbiome needs further study.Therefore,the purpose of this study was to investigate the effect of PRP treatment on scalp microbiota composition.Methods:We performed PRP treatment on 14 patients with AGA,observed their clinical efficacy,and collected scalp swab samples before and after treatment.The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.Results:The results showed that PRP was effective in the treatment of AGA patients,and the hair growth increased significantly.The results of relative abundance analysis of microbiota showed that after treatment,g_Cutibacterium increased and g_Staphylococcus decreased,which played a stable role in scalp microbiota.In addition,g_Lawsonella decreased,indicating that the scalp oil production decreased after treatment.Conclusions:The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.

关 键 词：androgenic alopecia MICROBIOME platelet-rich plasma SCALP 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]