Current status of nerve infiltration by skip metastases in colorectal cancer  

作　　者：Jie Zhou Yan-Wei Gao Ya-Dong Ji Ri-Na Su Shuang Zhang Ze-He Li 

机构地区：[1]Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia,China [2]Abdominal Tumor Surgery,Inner Mongolia Autonomous Region People’s Hospital,Hohhot 010017,Inner Mongolia,China [3]Baotou Medical College,Baotou 014000,Inner Mongolia,China [4]Gastroenterology Department,Arongqi People’s Hospital,Hulun Buir 021000,Inner Mongolia,China

出　　处：《Oncology and Translational Medicine》2024年第3期126-131,共6页肿瘤学与转化医学（英文版）

摘　　要：Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence rate of 24.07 per 10million,and 286,200 deaths.China accounts for approximately 30%of new cases and deaths from CRC worldwide,with East Asia accounting for over 75%.Initially,CRC presents as local tumor growth,but it has the potential to spread to other body parts over time.Perineural infiltration(PNI)is a relatively less discussed route of diffusion,yet it plays a crucial role in the progression and prognosis of CRC.PNI often occurs alongside local lymph nodes and distant metastases,posing challenges for treatment and management.Clinical symptoms,radiographic findings,and histopathological examination can be used to diagnose PNI with skipmetastasis.Symptoms commonly include local pain,paresthesia,andmotor impairment.Imaging helps identify the mass’s location and relationship to nerves,whereas histopathological examination confirms the diagnosis.Treatment of PNI skipmetastases is similar to other CRC metastases,including surgical resection,chemotherapy,radiotherapy,and targeted therapy.Surgical resection is the primary therapeutic approach,but the wider range of metastasis in PNI skip transfer may limit its feasibility.In cases where surgical resection is not possible,chemotherapy,radiotherapy,and targeted therapy are used to control tumor metastasis.In conclusion,PNI skip metastases increase the risk of poor prognosis for CRC,requiring a comprehensive approach with multiple treatments to prevent disease progression.Early detection and treatment are vital to improving prognosis.

关 键 词：Neve invasion in colorectal Skip metastases Perineural infiltration 

分 类 号：R735.34[医药卫生—肿瘤]