Landscape of urine biomarkers for bladder cancer:molecular function,cell-of-origin,and bibliometric trend  

作　　者：Min Liu Shuo Li Yuan Rong Fei Long Wu-Shi Zhao Yu-Xuan Qin Ting Wang Fu-Bing Wang Xiang-Yu Meng 

机构地区：[1]Department of Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [2]Center for Single-Cell Omics and Tumor Liquid Biopsy,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [3]School of Information Management,Wuhan University,Wuhan 430000,China [4]Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [5]Wuhan Research Center for Infectious Diseases and Cancer,Chinese Academy of Medical Sciences,Wuhan 430071,China [6]Health Science Center,Hubei Minzu University,Enshi 445000,China

出　　处：《Oncology and Translational Medicine》2024年第3期132-142,共11页肿瘤学与转化医学（英文版）

基　　金：supported by the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(FBW,grant ZNJC202210);the CAMS Innovation Fund for Medical Sciences(FBW,grant 2022-I2M-C&T-B-118);the National Natural Science Foundation of China(XYM,grant 82303057);the Natural Science Foundation of Hubei Province of China(XYM,grant 2023 AFB521).

摘　　要：Background:The effective management of bladder cancer(BCa)depends on the early diagnosis and surveillance.Previous studies have explored numerous urinary molecules as potential biomarkers of BCa.However,the molecular functions and cell-of-origin profiles of these biomarkers are yet to be elucidated.In this study,we aimed to provide a comprehensive overview of the landscape of urinary biomarker genes for BCa.Methods:We conducted an exhaustive literature search in PubMed,through which 555 biomarker genes were identified.We then analyzed the BCa single-cell atlas to infer the cellular origin of these BCa urine biomarker genes and performed functional enrichment analysis to gain insights into the functional molecular implications of these biomarkers.Results:These genes are involved in tumor proliferation,angiogenesis,cellmigration,and cell death and are predominantly expressed in epithelial and stromal cells.Interestingly,our analysis ofmultiomics tumor data revealed a discordance between tissue and urine in terms of differential methylation and RNA expression,suggesting that biomarker discovery for liquid biopsies should ideally begin with the analysis of bodily fluids rather than relying interest and that test strategies incorporating multiple molecular markers represent an ongoing trend.Conclusions:Collectively,our study has built a landscape of BCa urine biomarker genes,uncovered molecular insights into these biomarkers,and revealed the bibliometric trends in this field,which will contribute to the discovery of novel biomarkers in the future.

关 键 词：Bladder cancer Urine biomarker Molecular function Cell-of-origin BIBLIOMETRIC 

分 类 号：R737.14[医药卫生—肿瘤]