运动调控miRNA改善非酒精性脂肪性肝病机制的研究进展  

Research Progress on the Mechanism of Exercise Regulating miRNAs to Improve the Non-Alcoholic Fatty Liver Disease

作　　者：廖春旺 胡雪峰[2] 刘祖辉[1] LIAO Chunwang;HU Xuefeng;LIU Zuhui(College of Sports Science,Fujian Normal University,Fuzhou 350117,China;Fujian Key Laboratory of Developmental and Neuro Biology,College of Life Science,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学体育科学学院,福州350117 [2]福建省发育与神经生物学重点实验室,福建师范大学生命科学学院,福州350117

出　　处：《中国细胞生物学学报》2024年第5期1010-1020,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:81771034)资助的课题。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一类常见的慢性肝病,包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎等,常并发其他代谢病症,严重影响人类身体健康。运动锻炼作为预防与治疗NAFLD的一种有效方式,可以调控相关miRNA表达靶向干预NAFLD病程中的脂质代谢、炎症反应、氧化应激、肝细胞凋亡、肝组织纤维化等。该文梳理前人研究成果,阐述运动改善NAFLD过程中相关mi RNA的作用,探讨运动、miRNA、NAFLD之间的关系及运动调控miRNA表达改善NAFLD的机制,以期为运动干预治疗NAFLD机制探究提供参考。NAFLD(non-alcoholic fatty liver disease)is a common type of chronic liver disease,including non-alcoholic simple fatty liver,non-alcoholic steatohepatitis,etc.It is often complicated with other metabolic diseases,which seriously affects human health.As an effective way to prevent and treat NAFLD,exercise can regulate the expression of related miRNAs to target lipid metabolism,inflammation,oxidative stress,hepatocyte apoptosis,and hepatic tissue fibrosis in the course of NAFLD.The article combed through the previous research results and elaborated on the role of relevant miRNAs in the process of improvement of NAFLD by exercise,explored the relationship between exercise,miRNA,NAFLD,and the mechanism of exercise regulating miRNA expression to improve NAFLD,with a view to providing a reference for the exploration of the mechanism of exercise intervention in the treatment of NAFLD.

关 键 词：运动 非酒精性脂肪性肝病 MIRNA 

分 类 号：R575.5[医药卫生—消化系统]