氯吡格雷联合阿司匹林治疗女性大脑动脉狭窄所致脑梗死的临床效果  

Clinical effect of Clopidogrel combined with Aspirin in the treatment of female cerebral infarction caused by cerebral artery stenosis

作　　者：敬乃鲁 刘艳武 王汉林 JING Nailu;LIU Yanwu;WANG Hanlin(Department of Neurology,Lanling County People’s Hospital,Shandong Province,Lanling 277700,China)

机构地区：[1]山东省兰陵县人民医院神经内科,山东兰陵277700

出　　处：《妇儿健康导刊》2024年第10期30-33,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨氯吡格雷联合阿司匹林治疗女性大脑动脉狭窄所致脑梗死的临床效果。方法回顾性分析兰陵县人民医院2022年1月至2023年1月收治的84例大脑动脉狭窄所致脑梗死女性患者的临床资料,按照不同的治疗方法分为两组,各42例。对照组给予阿司匹林治疗,观察组在其基础上加用氯吡格雷治疗,比较两组临床疗效、神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、血液流变学指标、血小板聚集率及不良反应。结果与对照组(80.95%)相比,观察组治疗总有效率(95.24%)更高(P<0.05);治疗后,观察组NIHSS评分[(4.12±0.35)分]低于对照组[(7.49±1.22)分],纤维蛋白原[(3.35±0.26)g/L]、血浆黏稠度[(0.67±0.13)m Pa·s]、全血高切黏度[(7.36±1.05)m Pa·s]、全血低切黏度[(8.96±0.30)mPa·s]及血小板聚集率[(28.42±6.48)%]低于对照组[(4.95±0.36)g/L、(1.36±0.15)mPa·s、(10.82±5.26)mPa·s、(11.91±4.56)mPa·s及(34.66±6.87)%],差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林治疗女性大脑动脉狭窄所致脑梗死的临床效果较好,有助于促进患者神经功能恢复,改善血液流变学,降低血小板聚集率,值得推广。Objective To investigate the clinical effect of Clopidogrel combined with Aspirin in the treatment of female cerebral infarction caused by cerebral artery stenosis.Methods The clinical data of 84 female patients with cerebral infarction caused by cerebral artery stenosis admitted to Lanling County People’s Hospital from January 2022 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into two groups,with 42 cases in each group.The control group was treated with Aspirin,and the observation group was treated with Clopidogrel on the basis of Aspirin.The clinical efficacy,neurological deficit(National Institutes of Health stroke scale[NIHSS])score,hemorheology indexes,platelet aggregation rate,and adverse reactions were compared between the two groups.Results Compared with the control group(80.95%),the total effective rate of the observation group(95.24%)was higher(P<0.05).After treatment,the NIHSS score of the observation group([4.12±0.35]points)was lower than that of the control group([7.49±1.22]points).Fibrinogen([3.35±0.26]g/L),plasma viscosity([0.67±0.13]mPa·s),whole blood high shear viscosity([7.36±1.05]mPa·s),whole blood low shear viscosity([8.96±0.30]mPa·s),and platelet aggregation rate([28.42±6.48]%)were lower than those of the control group([4.95±0.36]g/L,[1.36±0.15]mPa·s,[10.82±5.26]mPa·s,[11.91±4.56]mPa·s,and[34.66±6.87]%),the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Clopidogrel combined with Aspirin in the treatment of female cerebral infar ction caused by cerebral artery stenosis has good clinical effect,which can help promote the recovery of neurological function,improve hemorheology,and reduce platelet aggregation rate,which is worthy of promotion.

关 键 词：氯吡格雷 阿司匹林 大脑动脉狭窄 脑梗死 神经功能损伤 血液流变学 血小板聚集率 

分 类 号：R743.33[医药卫生—神经病学与精神病学]