橘皮竹茹颗粒治疗恶性肿瘤患者化疗相关性恶心呕吐的临床疗效  

Clinical efficacy of orange peel and bamboo granule in the treatment of chemotherapy induced nausea and vomiting in patients with malignant tumors

作　　者：马俊 李忠锟 张宁倩 白连伟[2] 杨秋实 赵月鸣 郝杰 郭忠威 李制英[2] 杨焱[2] 张文凤 MA Jun;LI Zhongkun;ZHANG Ningqian;BAI Lianwei;YANG Qiushi;ZHAO Yueming;HAO Jie;GUO Zhongwei;LI Zhiying;YANG Yan;ZHANG Wenfeng(School of Traditional Chinese Medicine,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;Third Department of Internal Medicine,Jilin Cancer Hospital,Changchun 130021,Jilin,China;Shool of Medicine,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China)

机构地区：[1]长春中医药大学中医学院,长春130117 [2]吉林省肿瘤医院内三科,长春130021 [3]长春中医药大学基础医学院,长春130117

出　　处：《癌症进展》2024年第8期872-876,共5页Oncology Progress

基　　金：吉林省中医药科技项目(2023072);吉林省医药健康产业发展专项切块资金项目(20230404002TH)。

摘　　要：目的探讨橘皮竹茹颗粒治疗恶性肿瘤患者化疗相关性恶心呕吐(CINV)的临床疗效。方法采用随机数字表法将72例恶性肿瘤患者随机分为治疗组和对照组,每组36例,对照组患者采用常规止吐治疗,治疗组患者采用橘皮竹茹颗粒治疗联合常规止吐治疗。比较两组患者的恶心呕吐、食欲、中医证候积分改善情况以及健康状态[卡氏功能状态(KPS)评分]和生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQC30)]。结果治疗后,治疗组患者的恶心治疗总有效率为94.44%,高于对照组患者的72.22%,呕吐治疗总有效率为88.89%,高于对照组患者的63.89%,食欲不振治疗总有效率为88.89%,高于对照组患者的63.89%,差异均有统计学意义(P﹤0.05)。治疗后,治疗组患者的中医证候积分均低于本组治疗前和对照组,中医证候治疗总有效率为88.89%,高于对照组患者的69.44%,差异均有统计学意义(P﹤0.05)。治疗后,治疗组患者KPS、EORTC QLQ-C30评分均高于本组治疗前和对照组,差异均有统计学意义(P﹤0.05)。结论橘皮竹茹颗粒治疗恶性肿瘤患者CINV的疗效显著,可明显改善患者的食欲、健康状态和生活质量。Objective To observe the clinical efficacy of orange peel and bamboo granule in the treatment of chemotherapy induced nausea and vomiting(CINV)in patients with malignant tumors.Method A total of 72 malignant tumors patients were randomly divided into treatment group and control group using random number table method,with 36 cases in each group.The control group received routine antiemetic treatment,while the treatment group received orange peel and bamboo granule combined with routine antiemetic treatment.The nausea,vomiting,appetite,traditional Chinese medicine syndrome scores,as well as the health status[Karnofsky performance status(KPS)]and quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)]were compared between the two groups.Result After treatment,the total effective rate of nausea in the treatment group was 94.44%,which was higher than 72.22% in the control group,the total effective rate of vomiting was 88.89%,which was higher than 63.89% in the control group,the total effective rate of appetite loss was 88.89%,which was higher than 63.89% in the control group,and the differences were statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of the treatment group were lower than those before treatment and the control group,the total effective rate of traditional Chinese medicine syndrome was 88.89%,which was higher than 69.44% of the control group,and the differences were statistically significant(P<0.05).After treatment,the KPS and EORTC QLQ-C30 scores in the treatment group were higher than those before treatment and the control group,and the differences were statistically significant(P<0.05).Conclusion The efficacy of orange peel and bamboo granule on malignant tumor patients with CINV is significant,which can significantly improve the patient’s appetite,health status,and quality of life.

关 键 词：化疗相关性恶心呕吐 橘皮竹茹颗粒 恶性肿瘤 临床疗效 

分 类 号：R730.5[医药卫生—肿瘤]