炎症标志物在预测胰腺神经内分泌肿瘤预后中的应用进展  

Advances in prognostic value of inflammatory markers in pancreatic neuroendocrine neoplasms

作　　者：庞超宇 高鑫 樊知遥 展翰翔[1] Pang Chaoyu;Gao Xin;Fan Zhiyao;Zhan Hanxiang(Department of Pancreatic Surgery,Qilu Hospital,Shandong University,Ji′nan 250012,China)

机构地区：[1]山东大学齐鲁医院胰腺外科,济南250012

出　　处：《中华消化外科杂志》2024年第5期680-684,共5页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(81972274);泰山学者青年专家项目(tsqn202103172);山东省自然科学基金(ZR2021LSW004)。

摘　　要：胰腺神经内分泌肿瘤(pNEN)具有高度异质性,不同分期或分级的pNEN患者预后差别巨大,目前尚缺乏实用且灵敏的预后预测指标。炎症反应在肿瘤的发生发展中扮演重要角色,中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、淋巴细胞与单核细胞比值等炎症标志物在肿瘤的诊断及预后预测等方面具有重要意义,多项研究已证明各类炎症标志物与肿瘤的不良预后相关,可作为肿瘤预后的预测因子。笔者系统回顾炎症标志物与pNEN预后相关性的研究进展,以期为pNEN的临床决策提供思路和参考。Pancreatic neuroendocrine neoplasm(pNEN)is highly heterogeneous,and the prognosis varies among tumors of different stages and grades.However,there is lacking high prognostic predictors with sensitivity and specificity.Inflammation plays a pivotal role in the occurrence and development of different tumors,various inflammatory markers such as neutrophil-lymphocyte ratio,platelet‐lymphocyte ratio,lymphocyte‐monocyte ratio are of great significance in the diagnosis,treat-ment,and prognosis of tumors.Several studies have demonstrated that inflammatory markers are associated with poor prognosis and can serve as predictive factors for tumor prognosis.The authors summarize recent advances in the researches focused on the prognostic value of inflammatory markers in pNEN,in order to provide novel insights for clinical decision‐making of pNEN.

关 键 词：胰腺肿瘤 神经内分泌肿瘤 炎症标志物 预后 进展 

分 类 号：R735.9[医药卫生—肿瘤]