机械敏感性离子通道Piezo1在免疫细胞和胰腺炎中的 研究进展  

Research progress of mechanosensitive ion channel Piezo1 in immune cells and pancreatitis

作　　者：刘如娟 王铮[2] 文礼 曹锋[3] Liu Rujuan;Wang Zheng;Wen Li;Cao Feng(Biomarker Research Platform,Clinical Medical Research Institute,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100073,China;Department of Hepatobiliary Surgery,The First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China;Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]中国医学科学院北京协和医院临床医学研究所生物标志物研究平台,北京100073 [2]西安交通大学第一附属医院肝胆外科,西安710061 [3]首都医科大学宣武医院普通外科,北京100053

出　　处：《中华消化外科杂志》2024年第5期754-760,共7页Chinese Journal of Digestive Surgery

基　　金：中央高水平临床科研专项(2022‑PUMCH‑E‑003);中国医学科学院医学与健康科技创新工程(2023‑I2M‑3‑001);国家自然科学基金(82122010、82070659);北京自然科学基金(7242069)。

摘　　要：Piezo1作为机械敏感性离子通道,在多种免疫细胞中均表达且通过响应机械信号介导钙离子内流,在机体免疫反应中发挥重要调控作用。胰腺实质细胞对机械应力具有高敏感性,Piezo1能响应胰腺炎病因及病情进展过程中的机械刺激,引起胰腺实质细胞或胰腺星状细胞钙离子内流并参与调控胰腺炎相关病理学改变。笔者总结近年来Piezo1在各类免疫细胞和急、慢性胰腺炎中作用及调控机制的最新研究进展,并对免疫细胞Piezo1在急、慢性胰腺炎中的作用进行讨论,以期为胰腺炎早期预防和治疗提供新策略和新靶点。As a mechanosensitive ion channel,Piezo1 is expressed in various immune cells and plays an important role in mediating immune response by calcium influx in response to mechanical signals.Pancreatic parenchymal cells are highly sensitive to mechanical stress.Piezo1 can respond to mechanical stimuli during the initiation and development of pancreatitis.The authors summarize the latest research advancements on the role and molecular mechanisms of Piezo1 in various immune cells and pancreatitis in recent years and discuss the potential role of immune cell Piezo1 in acute and chronic pancreatitis,with an attempt to provide new insights for early intervention of pancreatitis.

关 键 词：胰腺炎 机械信号 免疫细胞 离子通道 Piezo1 

分 类 号：R576[医药卫生—消化系统]