早期肾癌局灶治疗的研究进展  

Research progress on focal therapy for early-stage renal cell carcinoma

作　　者：柳文强 宋家璈 陈童 吴震杰 王林辉 Liu Wenqiang;Song Jiaao;Chen Tong;Wu Zhenjie;Wang Linhui(Department of Urology,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院,上海200433

出　　处：《中华泌尿外科杂志》2024年第5期397-400,共4页Chinese Journal of Urology

基　　金：国家自然科学基金面上项目(82372883);上海市重中之重(2022ZZ01011)。

摘　　要：肾癌的局灶治疗是通过局部干预直接破坏肾癌病灶,同时最大限度保留周围健康肾组织的精准治疗技术,主要适用于Tla期(肿瘤直径≤4cm)的早期肾癌,尤其是手术风险较高的患者。相比于传统的根治性肾切除术和肾部分切除术,局灶治疗具有对患者一般情况要求低、更加微创、并发症少、恢复快等优势。目前临床上使用的局灶治疗技术主要包括冷冻消融、射频消融、微波消融、不可逆性电穿孔、高强度聚焦超声以及立体定向消融体部放疗。本文综述各种局灶治疗技术的原理、患者的选择,以及局灶治疗技术的肿瘤学结局、并发症和肾功能保护情况。Focal therapy for renal cell carcinoma is a precision treatment technique that directly targets and destroys cancerous lesions while preserving the maximum amount of surrounding healthy kidney tissue through localized intervention.It is primarily indicated for early-stage renal cell carcinoma in patients with tumors≤4 cm in diameter(Tra),particularly for those at higher surgical risk.Compared to traditional radical nephrectomy and partial nephrectomy,focal therapy offers several advantages,including lower physical demands on the patient,minimally invasive nature,reduced risk of complications,and faster recovery.The focal therapy techniques currently utilized in clinical practice include cryoablation,radiofrequency ablation,microwave ablation,irreversible electroporation,high-intensity focused ultrasound,and stereotactic body radiotherapy.This article reviews the principles of various focal therapy techniques,patient selection,and the oncological outcomes,complications,and renal function preservation associated with these focal therapies.

关 键 词：肾肿瘤 早期 局灶治疗 消融治疗 

分 类 号：R737.11[医药卫生—肿瘤]