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作 者:吴白露 李臻[1] 韩新巍[1] 李鑫[1] 谢炳灿 张玉元 余鹏 李一帆 吕培杰[2] 葛鹏磊 程兵[4] WU Baiu;LI Zhen;HAN Xinwei(Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province 450052,P.R.China)
机构地区:[1]郑州大学第一附属医院放射介入科,450052 [2]郑州大学第一附属医院放射科,450052 [3]郑州大学第一附属医院肝胆外科,450052 [4]郑州大学第一附属医院核医学科,450052
出 处:《临床放射学杂志》2024年第5期827-831,共5页Journal of Clinical Radiology
基 金:国家自然科学基金项目(编号:U1904143);省部共建重点项目(编号:SBGJ202102099);河南省重大公益专项资助项目(编号:201300310400)。
摘 要:目的探讨PD-1抗体联合安罗替尼及^(125)I粒子链置入治疗肝门部胆管癌的初步疗效及安全性。方法回顾性分析3例肝门部胆管癌患者的临床资料,均经病理结合实验室检查及影像学检查确诊,在DSA引导下行经皮肝穿胆道造影术,置入胆道支架及^(125)I粒子引流管,后续配合替雷利珠单抗及安罗替尼规律治疗。结果3例患者手术均成功,粒子引流管有效覆盖胆管病变区域,配合替雷利珠单抗及安罗替尼等药物治疗后病情均得到有效控制。结论替雷利珠单抗联合安罗替尼及^(125)I粒子链置入治疗肝门部胆管癌安全有效。Objective To investigate the initial efficacy and safety of PD-1 antibody combined with antirotinib and^(125)I seed chain implantation in the treatment of perihilar cholangiocarcinoma.Methods Clinical data of 3 patients with perihilar cholangiocarcinoma admitted to our department from April to January 2021 were retrospectively analyzed.All of them were confirmed by pathology combined with laboratory examination and imaging examination.Under the guidance of DSA,percutaneous transhepatic cholangiography was performed,biliary stent and^(125)I particle drainage tube were inserted,and then regular treatment was performed with tirelizumab and anrotinib.Results All the three patients were successfully operated.Particle drainage tube effectively covered the diseased area of bile duct,and the disease conditions were effectively controlled after treatment with tiralizumab and anrotinib.Conclusion Tirelizumab combined with allotinib and^(125)I seed chain implantation is safe and effective in the treatment of perihilar cholangiocarcinoma.
关 键 词:肝门部胆管癌 ^(125)I粒子链 替雷利珠单抗 安罗替尼 联合治疗
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